PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22419031-4	2013	The cytostatic activity of narciclasine involves the impairment of actin cytoskeleton organization by targeting GTPases, including RhoA and the elongation factor eEF1A.	narciclasine	27-39	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	162-167	
20643906-2	2010	This study indicates that such resistance can be overcome, at least partly, through the targeting of eEF1A elongation factor with narciclasine, an Amaryllidaceae isocarbostyril controlling plant growth.	narciclasine	130-142	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	101-106	
20643906-6	2010	The eEF1A targeting with narciclasine (50 nM) leads to 1) marked actin cytoskeleton disorganization, resulting in cytokinesis impairment, and 2) protein synthesis impairment (elongation and initiation steps), whereas apoptosis is induced at higher doses only (>=200 nM).	narciclasine	25-37	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	4-9	
20643906-7	2010	In addition to molecular docking validation and identification of potential binding sites, we biochemically confirmed that narciclasine directly binds to human recombinant and yeast-purified eEF1A in a nanomolar range, but not to actin or elongation factor 2, and that 5 nM narciclasine is sufficient to impair eEF1A-related actin bundling activity.	narciclasine	123-135	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	191-196	
20643906-7	2010	In addition to molecular docking validation and identification of potential binding sites, we biochemically confirmed that narciclasine directly binds to human recombinant and yeast-purified eEF1A in a nanomolar range, but not to actin or elongation factor 2, and that 5 nM narciclasine is sufficient to impair eEF1A-related actin bundling activity.	narciclasine	123-135	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	311-316	
20643906-8	2010	eEF1A is thus a potential target to combat melanomas regardless of their apoptosis-sensitivity, and this finding reconciles the pleiotropic cytostatic of narciclasine.	narciclasine	154-166	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	0-5