PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25893083-7 2015 nNOS forms nitric oxide (NO), which reacts with superoxide (O2 (-)) to form peroxynitrite (ONOO(-)). onoo 91-95 nitric oxide synthase 1 Homo sapiens 0-4 20623541-2 2010 Low concentrations of arachidonic acid (ARA; i.e., <0.1 microM) cause tyrosine kinase-dependent inhibition of neuronal nitric oxide synthase (nNOS) activity, thereby suppressing formation of ONOO(-) and the ensuing lethal response. onoo 194-198 nitric oxide synthase 1 Homo sapiens 113-143 21613472-4 2011 In turn, hippocampal nNOS-derived nitric oxide (NO) significantly downregulated local glucocorticoid receptor expression through both soluble guanylate cyclase (sGC)/cGMP and peroxynitrite (ONOO(-))/extracellular signal-regulated kinase signal pathways, and therefore elevated hypothalamic corticotrophin-releasing factor, a peptide that governs the hypothalamic-pituitary-adrenal axis. onoo 190-194 nitric oxide synthase 1 Homo sapiens 21-25 20623541-2 2010 Low concentrations of arachidonic acid (ARA; i.e., <0.1 microM) cause tyrosine kinase-dependent inhibition of neuronal nitric oxide synthase (nNOS) activity, thereby suppressing formation of ONOO(-) and the ensuing lethal response. onoo 194-198 nitric oxide synthase 1 Homo sapiens 145-149 20623541-7 2010 Early nNOS inhibition mediated by very low levels of ARA is indeed critical for nuclear factor-kappaB activation, which is otherwise effectively inhibited by constitutive nitric oxide, and for preventing early formation of ONOO(-). onoo 223-227 nitric oxide synthase 1 Homo sapiens 6-10 18201545-6 2008 Furthermore, treatment with either ONOO- or O2.- stimulated nNOS uncoupling with decreased NO and enhanced O2.- generation. onoo 35-39 nitric oxide synthase 1 Homo sapiens 60-64 11020342-1 2000 Much evidence supports a role of nitric oxide (.NO) and peroxynitrite (ONOO(-)) in experimental and idiopathic Parkinson"s disease (PD); moreover, an overexpression of neuronal nitric oxide synthase (nNOS) was recently reported in the basal ganglia of PD patients. onoo 71-75 nitric oxide synthase 1 Homo sapiens 168-198