PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31092012-7	2019	Nicotine increased the levels of iNOS (inducible nitric oxide synthase) and the co-staining of SIRT1 and 3-nitrotyrosine, a footprint of ONOO- in aortas.	onoo	137-141	sirtuin 1	Mus musculus	95-100	
31092012-8	2019	Tempol, which ablated ONOO- by scavenging superoxide anion, reduced the effects of nicotine on SIRT1 and collagen.	onoo	22-26	sirtuin 1	Mus musculus	95-100	
31092012-10	2019	Furthermore, ONOO- dose-dependently inhibited the enzyme and increased zinc release in recombinant SIRT1.	onoo	13-17	sirtuin 1	Mus musculus	99-104	
31092012-11	2019	Finally, we found SIRT1 inactivation by ONOO- activated the YAP (Yes-associated protein) resulting in abnormal ECM (extracellular matrix) remodeling.	onoo	40-44	sirtuin 1	Mus musculus	18-23	
31092012-12	2019	Conclusions- Nicotine induces ONOO-, which selectively inhibits SIRT1 resulting in a YAP-mediated ECM remodeling.	onoo	30-34	sirtuin 1	Mus musculus	64-69