PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33521454-5	2021	Additionally, roflumilast prevented IL-18-induced expressions and secretions of pro-inflammatory cytokines such as IL-6, IL-8, and TNF-alpha.	Roflumilast	14-25	interleukin 6	Homo sapiens	115-119	
33644540-11	2021	Results: The upregulated iNOS, excessive production of NO, IL-6, and MCP-1, and activated COX-2/PGE2 signaling pathways in the astrocytes induced by isoflurane were significantly reversed by the introduction of roflumilast, in a dose-dependent manner.	Roflumilast	211-222	interleukin 6	Homo sapiens	59-63	
33363471-6	2020	Results: At a clinically relevant concentration (1 nM), roflumilast N-oxide and roflumilast consistently reduced the release of TNF-alpha, CCL2, CCL3, CCL4, CCL5 and CXCL9 (but not CXCL1, CXCL5, CXCL8 and IL-6) from human bronchial explants.	Roflumilast	56-67	interleukin 6	Homo sapiens	205-209	
33363471-6	2020	Results: At a clinically relevant concentration (1 nM), roflumilast N-oxide and roflumilast consistently reduced the release of TNF-alpha, CCL2, CCL3, CCL4, CCL5 and CXCL9 (but not CXCL1, CXCL5, CXCL8 and IL-6) from human bronchial explants.	Roflumilast	80-91	interleukin 6	Homo sapiens	205-209	
32449901-11	2020	The production of TNF-alpha, IL-6, and IL-1ss was significantly suppressed by roflumilast.	Roflumilast	78-89	interleukin 6	Homo sapiens	29-33