PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27051648-6	2016	In the present study, the protective effects of hyperoside against hydrogen peroxide-induced oxidative stress in human lens epithelial cells, HLE-B3, were investigated in terms of HO-1 induction.	hyperoside	48-58	heme oxygenase 1	Homo sapiens	180-184	
27051648-11	2016	RESULTS: Hyperoside increased both the mRNA and protein expression of HO-1 in a time- and dose-dependent manner.	hyperoside	9-19	heme oxygenase 1	Homo sapiens	70-74	
27051648-14	2016	CONCLUSIONS: Hyperoside is an effective compound to protect cells against oxidative stress via HO-1 induction.	hyperoside	13-23	heme oxygenase 1	Homo sapiens	95-99	
26674355-2	2015	Our previous study demonstrated that the flavonoid hyperoside elicits cytoprotection against oxidative stress by activating the Keap1-Nrf2-ARE signaling pathway, thus increasing the expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) and catalase.	hyperoside	51-61	heme oxygenase 1	Homo sapiens	225-241	
26674355-2	2015	Our previous study demonstrated that the flavonoid hyperoside elicits cytoprotection against oxidative stress by activating the Keap1-Nrf2-ARE signaling pathway, thus increasing the expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) and catalase.	hyperoside	51-61	heme oxygenase 1	Homo sapiens	243-247	
26674355-6	2015	Further study showed that LiCl and siRNA-mediated inhibition of GSK-3beta increased hyperoside-induced HO-1 expression, and the effect was dependent upon enhanced Nrf2 nuclear translocation and gene expression.	hyperoside	84-94	heme oxygenase 1	Homo sapiens	103-107	
26674355-8	2015	Furthermore, the siRNA-mediated inhibition of Keap1 also enhanced hyperoside-induced Nrf2 nuclear accumulation and HO-1 expression, which was relatively smaller than the effects obtained from GSK-3beta siRNA administration.	hyperoside	66-76	heme oxygenase 1	Homo sapiens	115-119	
21689633-4	2011	Hyperoside further enhanced the cellular antioxidant defense system through increasing the activity of heme oxygenase-1 (HO-1), and by up-regulating HO-1 expression.	hyperoside	0-10	heme oxygenase 1	Homo sapiens	103-119	
21689633-4	2011	Hyperoside further enhanced the cellular antioxidant defense system through increasing the activity of heme oxygenase-1 (HO-1), and by up-regulating HO-1 expression.	hyperoside	0-10	heme oxygenase 1	Homo sapiens	121-125	
21689633-4	2011	Hyperoside further enhanced the cellular antioxidant defense system through increasing the activity of heme oxygenase-1 (HO-1), and by up-regulating HO-1 expression.	hyperoside	0-10	heme oxygenase 1	Homo sapiens	149-153	
21689633-6	2011	Collectively, our data provide the first description of the mechanism underlying hyperoside"s ability to attenuate H(2)O(2)-induced cell damage, namely this compound interacts with the MAPK-dependent Keap(1)-Nrf(2)-ARE signaling pathway to up-regulate HO-1 expression and enhance intracellular antioxidant activity.	hyperoside	81-91	heme oxygenase 1	Homo sapiens	252-256