PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34051675-3 2021 Recently, crystal structures of artemisinins with two mammalian targets were determined, namely, gephyrin, the prime scaffolding protein at inhibitory postsynapses, and pyridoxal kinase, a central metabolic enzyme synthesizing vitamin B6. Artemisinins 32-44 gephyrin Homo sapiens 97-105 30704910-4 2019 These artemisinins target the universal inhibitory neurotransmitter receptor-binding epitope of gephyrin, thus inhibiting critical interactions between gephyrin and glycine receptors (GlyRs) as well as GABAARs. Artemisinins 6-18 gephyrin Homo sapiens 96-104 31293385-7 2019 Small-molecule artemisinins and peptides derived from endogenous interactors, that specifically target the universal receptor binding site of gephyrin, acutely affect synaptic GABAAR numbers and clustering, modifying neuronal transmission. Artemisinins 15-27 gephyrin Homo sapiens 142-150 30704910-4 2019 These artemisinins target the universal inhibitory neurotransmitter receptor-binding epitope of gephyrin, thus inhibiting critical interactions between gephyrin and glycine receptors (GlyRs) as well as GABAARs. Artemisinins 6-18 gephyrin Homo sapiens 152-160 30704910-5 2019 Electrophysiological recordings reveal a significant inhibition of gephyrin-mediated neurotransmission by artemisinins. Artemisinins 106-118 gephyrin Homo sapiens 67-75