PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27071938-0 2016 Reversible immortalization of sheep fetal fibroblast cells by tetracycline-inducible expression of human telomerase reverse transcriptase. Tetracycline 62-74 telomerase reverse transcriptase Homo sapiens 105-137 28584529-0 2017 hTERT-Immortalized Bone Mesenchymal Stromal Cells Expressing Rat Galanin via a Single Tetracycline-Inducible Lentivirus System. Tetracycline 86-98 telomerase reverse transcriptase Homo sapiens 0-5 30603914-0 2019 The proliferative lifespan of adult sheep fibroblasts can be conditionally extended by tetracycline-inducible expression of human telomerase reverse transcriptase. Tetracycline 87-99 telomerase reverse transcriptase Homo sapiens 130-162 30603914-2 2019 Here, we report conditional extension of proliferative lifespan of adult sheep somatic cells by introducing tetracycline-inducible (Tet-on) expression of hTERT. Tetracycline 108-120 telomerase reverse transcriptase Homo sapiens 154-159 30603914-3 2019 After transfecting adult sheep fibroblasts with the vector for Tet-on induced conditional expression of hTERT, we obtained several hTERT-positive clones that exhibited extended-lifespan under the induction of tetracycline analogue, doxycycline. Tetracycline 209-221 telomerase reverse transcriptase Homo sapiens 131-136 25047146-6 2017 hTERT-CTLA4Ig hBMSCs retained their capacity for osteogenic differentiation in vitro, shown by the detection of hydroxyapatite mineral deposition (labelled tetracycline fluorescence staining), calcareous nodules (alizarin red S staining), alkaline phosphatase (calcium-cobalt method) and osteocalcin (immunocytochemistry). Tetracycline 156-168 telomerase reverse transcriptase Homo sapiens 0-5 27071938-1 2016 OBJECTIVES: To achieve reversible immortalization of cells, we design a modified tetracycline-inducible expression (Tet-on) system to conditionally regulate the ectopic expression of human telomerase reverse transcriptase (hTERT) in primary cells. Tetracycline 81-93 telomerase reverse transcriptase Homo sapiens 189-221 27071938-1 2016 OBJECTIVES: To achieve reversible immortalization of cells, we design a modified tetracycline-inducible expression (Tet-on) system to conditionally regulate the ectopic expression of human telomerase reverse transcriptase (hTERT) in primary cells. Tetracycline 81-93 telomerase reverse transcriptase Homo sapiens 223-228 17984977-4 2008 We designed two tetracycline-inducible recombinant adenoviruses using the human telomerase reverse transcriptase (hTERT) promoter for transcriptional apoptogene targeting. Tetracycline 16-28 telomerase reverse transcriptase Homo sapiens 80-112 26427661-0 2016 Synthetic Tet-inducible small hairpin RNAs targeting hTERT or Bcl-2 inhibit malignant phenotypes of bladder cancer T24 and 5637 cells. Tetracycline 10-13 telomerase reverse transcriptase Homo sapiens 53-58 18540079-1 2008 We constructed a novel cancer-specific regulatable adenoviral expression system comprising two vectors: one expressing rtTA, a reverse tetracycline transactivator regulated by the human telomerase reverse transcriptase (hTERT) gene promoter, the other expressing the target gene regulated by the tetracycline response element (TRE). Tetracycline 135-147 telomerase reverse transcriptase Homo sapiens 220-225 17984977-4 2008 We designed two tetracycline-inducible recombinant adenoviruses using the human telomerase reverse transcriptase (hTERT) promoter for transcriptional apoptogene targeting. Tetracycline 16-28 telomerase reverse transcriptase Homo sapiens 114-119 12101414-5 2002 The hTERT promoter drives the expression of tTA, a transactivator capable of binding to TRE (tetracycline-responsive element) in the absence of tetracycline, which in turn induces expression of the GFP-Bax gene. Tetracycline 93-105 telomerase reverse transcriptase Homo sapiens 4-9 34456193-4 2021 Methods and Results: The lentivirus system driven by tetracycline (TET)-on carrying Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, hTERT, and SV40LT (OSKMNLST) could reprogram sheep kidney cells into pluripotent cells. Tetracycline 53-65 telomerase reverse transcriptase Homo sapiens 123-128