PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35514319-0 2022 Icariin inhibits the malignant progression of lung cancer by affecting the PI3K/Akt pathway through the miR-205-5p/PTEN axis. icariin 0-7 phosphatase and tensin homolog Homo sapiens 115-119 35514319-9 2022 Importantly, rescue experiment results showed that ICA could target the miR-205-5p/PTEN axis to affect the PI3K/Akt signaling, thereby suppressing the malignant cell phenotype of lung cancer. icariin 51-54 phosphatase and tensin homolog Homo sapiens 83-87 32581820-9 2020 Accordingly, PTEN overexpression obviously abolished the protective effects of icariin on Abeta-induced insulin resistance. icariin 79-86 phosphatase and tensin homolog Homo sapiens 13-17 32581820-8 2020 Icariin treatment markedly reduced Abeta-enhanced PTEN protein levels, leading to an improvement in Abeta-induced insulin resistance. icariin 0-7 phosphatase and tensin homolog Homo sapiens 50-54 32581820-12 2020 Taken together, these results suggest that icariin protects SK-N-MC cells against Abeta-induced insulin resistance by activating the proteasome-dependent degradation of PTEN. icariin 43-50 phosphatase and tensin homolog Homo sapiens 169-173 30038846-5 2018 Multiple targets and mechanisms of ICA are reported which relates to regulate lymphocytes balance, anti-inflammatory/inflammatory cytokines, signal pathways like NF-kappabeta and Erk-p38-JNK, lymphocyte transcription factors and other targets such as TLRs, STAT and PTEN, etc. icariin 35-38 phosphatase and tensin homolog Homo sapiens 266-270