PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35514319-0	2022	Icariin inhibits the malignant progression of lung cancer by affecting the PI3K/Akt pathway through the miR-205-5p/PTEN axis.	icariin	0-7	phosphatase and tensin homolog	Homo sapiens	115-119	
35514319-9	2022	Importantly, rescue experiment results showed that ICA could target the miR-205-5p/PTEN axis to affect the PI3K/Akt signaling, thereby suppressing the malignant cell phenotype of lung cancer.	icariin	51-54	phosphatase and tensin homolog	Homo sapiens	83-87	
30038846-5	2018	Multiple targets and mechanisms of ICA are reported which relates to regulate lymphocytes balance, anti-inflammatory/inflammatory cytokines, signal pathways like NF-kappabeta and Erk-p38-JNK, lymphocyte transcription factors and other targets such as TLRs, STAT and PTEN, etc.	icariin	35-38	phosphatase and tensin homolog	Homo sapiens	266-270	
32581820-9	2020	Accordingly, PTEN overexpression obviously abolished the protective effects of icariin on Abeta-induced insulin resistance.	icariin	79-86	phosphatase and tensin homolog	Homo sapiens	13-17	
32581820-12	2020	Taken together, these results suggest that icariin protects SK-N-MC cells against Abeta-induced insulin resistance by activating the proteasome-dependent degradation of PTEN.	icariin	43-50	phosphatase and tensin homolog	Homo sapiens	169-173	
32581820-8	2020	Icariin treatment markedly reduced Abeta-enhanced PTEN protein levels, leading to an improvement in Abeta-induced insulin resistance.	icariin	0-7	phosphatase and tensin homolog	Homo sapiens	50-54