PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25112719-0	2015	Icariin may benefit the mesenchymal stem cells of patients with steroid-associated osteonecrosis by ABCB1-promoter demethylation: a preliminary study.	icariin	0-7	ATP binding cassette subfamily B member 1	Homo sapiens	100-105	
25747987-0	2015	Icariin enhances cytotoxicity of doxorubicin in human multidrug-resistant osteosarcoma cells by inhibition of ABCB1 and down-regulation of the PI3K/Akt pathway.	icariin	0-7	ATP binding cassette subfamily B member 1	Homo sapiens	110-115	
25747987-7	2015	In addition, an increase in Rh123 accumulation and a decrease in Rh123 efflux were observed in MG-63/DOX cells treated with icariin, indicating a blockage of the activity of MDR1.	icariin	124-131	ATP binding cassette subfamily B member 1	Homo sapiens	174-178	
25747987-8	2015	Furthermore, icariin enhanced the apoptosis induced by doxorubicin and down-regulated the expression of MDR1.	icariin	13-20	ATP binding cassette subfamily B member 1	Homo sapiens	104-108	
25747987-10	2015	In conclusion, icariin possesses a reversal effect on multidrug resistance in MG-63/DOX cells through down-regulation of the MDR1 and the PI3K/Akt pathway, and has the potential to be an adjunct to chemotherapy for osteosarcoma.	icariin	15-22	ATP binding cassette subfamily B member 1	Homo sapiens	125-129	
25112719-1	2015	UNLABELLED: In this study, we found out a previously undefined function of icariin which restored the dynamic balance between osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs) in patients with osteonecrosis of femoral head (ONFH) via ABCB1-promoter demethylation.	icariin	75-82	ATP binding cassette subfamily B member 1	Homo sapiens	259-264	
25112719-7	2015	Treatment with icariin obviously induced de novo P-gp expression, decreased oxidative stress, and promoted osteogenesis.	icariin	15-22	ATP binding cassette subfamily B member 1	Homo sapiens	49-53