PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30551489-6 2019 Furthermore, icariin pretreatment reduced NF-kappaB phosphorylation and nuclear translocation in HEK-293 cells followed by decreased secretion of IL-1beta, TNF-alpha, and iNOS, suggesting a suppression of inflammatory response. icariin 13-20 tumor necrosis factor Homo sapiens 156-165 32550884-7 2020 Furthermore, icariin significantly increased protein expression of the anti-inflammatory factor interleukin (IL)-10 and significantly decreased protein expression of the pro-inflammatory factors IL-8 and tumor necrosis factor alpha. icariin 13-20 tumor necrosis factor Homo sapiens 204-231 33849528-9 2021 Additionally, the results clarified that ICA significantly inhibited the migration, invasion capacity, and expression levels of TGF-beta1, TNF-alpha, IL-6, IL-17A, IL-10 in SiHa cells. icariin 41-44 tumor necrosis factor Homo sapiens 139-148 26507164-9 2015 Icariin treatment resulted in a reduced expression of p-P38 and p-ERK signal activation induced by TNF-alpha/IFN-gamma; however, only SB203580, the p38 alpha/beta inhibitor, inhibited the secretion of inflammatory cytokines induced by TNF-alpha/IFN-gamma in cultured HaCaT cells. icariin 0-7 tumor necrosis factor Homo sapiens 99-108 26507164-9 2015 Icariin treatment resulted in a reduced expression of p-P38 and p-ERK signal activation induced by TNF-alpha/IFN-gamma; however, only SB203580, the p38 alpha/beta inhibitor, inhibited the secretion of inflammatory cytokines induced by TNF-alpha/IFN-gamma in cultured HaCaT cells. icariin 0-7 tumor necrosis factor Homo sapiens 235-244 26507164-10 2015 The differential expression of TNF-alpha-R1 and IFN-gamma-R1 was also observed after the stimulation of TNF-alpha/IFN-gamma, which was significantly normalized after the icariin treatment. icariin 170-177 tumor necrosis factor Homo sapiens 31-40 26507164-10 2015 The differential expression of TNF-alpha-R1 and IFN-gamma-R1 was also observed after the stimulation of TNF-alpha/IFN-gamma, which was significantly normalized after the icariin treatment. icariin 170-177 tumor necrosis factor Homo sapiens 104-113 25472572-4 2015 RESULTS: The in vivo results demonstrated that ICA pretreatment significantly improved I/R-induced tissue damage and decreased serum tumor necrosis factor alpha and interleukin-6 levels. icariin 47-50 tumor necrosis factor Homo sapiens 133-160 25688369-4 2015 ICA upregulated the expression of SIRT6 and had an inhibitory effect on NF-kappaB inflammatory signaling pathways as shown by decreasing mRNA levels of the NF-kappaB downstream target genes TNF-alpha, ICAM-1, IL-2, and IL-6. icariin 0-3 tumor necrosis factor Homo sapiens 190-199 34147477-4 2021 Our results showed that both icariin and icaritin significantly inhibited LPS-induced mRNA expressions of tumor necrosis factor (TNF-alpha) and interleukin-1beta (IL-1beta). icariin 29-36 tumor necrosis factor Homo sapiens 106-127 34147477-4 2021 Our results showed that both icariin and icaritin significantly inhibited LPS-induced mRNA expressions of tumor necrosis factor (TNF-alpha) and interleukin-1beta (IL-1beta). icariin 29-36 tumor necrosis factor Homo sapiens 129-138 34147477-5 2021 Pre-treatment with IGF-1 receptor antagonist JB-1 could significantly block the anti-inflammatory effects of icariin and icaritin on LPS-induced up-regulations of TNF-alpha, IL-1beta, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). icariin 109-116 tumor necrosis factor Homo sapiens 163-172 35114909-2 2022 Our previous research showed that TNF, MMP9, STAT3, PIK3CA, ERBB2, MTOR, IL2, PTGS2, KDR and F2 are important targets of ICA in the treatment of OC. icariin 121-124 tumor necrosis factor Homo sapiens 34-37 29767263-5 2018 In addition, icariin inhibited the production of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha and induced the production of IL-10. icariin 13-20 tumor necrosis factor Homo sapiens 72-105 26507164-0 2015 Icariin inhibits TNF-alpha/IFN-gamma induced inflammatory response via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes. icariin 0-7 tumor necrosis factor Homo sapiens 17-26 26507164-3 2015 In this study, we evaluated the anti-inflammatory potential and mechanisms of icariin in the tumor necrosis factor-alpha (TNF-alpha)/interferon-gamma (IFN-gamma)-induced inflammatory response in human keratinocytes (HaCaT cells) by observing these cells in the presence or absence of icariin. icariin 78-85 tumor necrosis factor Homo sapiens 93-120 26507164-3 2015 In this study, we evaluated the anti-inflammatory potential and mechanisms of icariin in the tumor necrosis factor-alpha (TNF-alpha)/interferon-gamma (IFN-gamma)-induced inflammatory response in human keratinocytes (HaCaT cells) by observing these cells in the presence or absence of icariin. icariin 78-85 tumor necrosis factor Homo sapiens 122-131 26507164-8 2015 We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner. icariin 14-21 tumor necrosis factor Homo sapiens 32-41 26507164-8 2015 We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner. icariin 146-153 tumor necrosis factor Homo sapiens 32-41 35442463-17 2022 CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD. icariin 17-24 tumor necrosis factor Homo sapiens 246-249