PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30146016-7 2018 We also detected the macrophage infiltration, NF-kappaB activation, NLRP3 inflammasome activation and inflammatory cytokine TNF-alpha production in MRL/lpr mice after icariin treatment. icariin 167-174 tumor necrosis factor Mus musculus 124-133 29873273-5 2019 Compounds icariin (2) and epimedin C (3) were found to inhibit the secretion of TNF-alpha to a comparable degree as quercetin. icariin 10-17 tumor necrosis factor Mus musculus 80-89 30146016-10 2018 Icariin inhibited NF-kappaB activation and TNF-alpha production in MRL/lpr mice. icariin 0-7 tumor necrosis factor Mus musculus 43-52 21538629-4 2011 Several molecules, such as myeloid differentiation factor 88, tumor necrosis factor-alpha and interleukin 6, which are involved in the TLR9 downstream signaling pathway, were also significantly up-regulated in response to icariin stimulation. icariin 222-229 tumor necrosis factor Mus musculus 27-89 25089961-4 2014 RESULTS: We found that icariin significantly protected pulmonary function and attenuated CS-induced inflammatory response by decreasing inflammatory cells and production of TNF-alpha, IL-8 and MMP-9 in both the serum and BALF of CS-exposed mice and decreasing production of TNF-alpha and IL-8 in the supernatant of CSE-exposed A549 cells. icariin 23-30 tumor necrosis factor Mus musculus 173-182 25089961-4 2014 RESULTS: We found that icariin significantly protected pulmonary function and attenuated CS-induced inflammatory response by decreasing inflammatory cells and production of TNF-alpha, IL-8 and MMP-9 in both the serum and BALF of CS-exposed mice and decreasing production of TNF-alpha and IL-8 in the supernatant of CSE-exposed A549 cells. icariin 23-30 tumor necrosis factor Mus musculus 274-283 25985156-12 2015 In addition, immunohistochemical analysis and enzyme-linked immunosorbent assay showed icariin significantly reduced expression and secretion of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 in the calvariae of titanium-stimulated mice. icariin 87-94 tumor necrosis factor Mus musculus 145-172 34803690-10 2021 Following icariin treatment, significant decreases were observed in CoCrMo wear particle-induced TNF-alpha and IL-6 mRNA expression in BMDMs, and osteolysis in mice calvaria. icariin 10-17 tumor necrosis factor Mus musculus 97-106 20519138-4 2010 In addition, icariin suppressed the secretion of TNF-alpha, prostaglandin E2 (PGE(2)) and nitric oxide (NO) as well as NF-kappaB p65 activation. icariin 13-20 tumor necrosis factor Mus musculus 49-58 18992191-5 2008 ICA decreased the secretion of IL-2, IL-4 and IL-10 but increased that of TNF-alpha and IFN-gamma. icariin 0-3 tumor necrosis factor Mus musculus 74-83 33798737-4 2021 In addition, icariin improved the intestinal integrity of the aged mice by upregulating tight junction adhesion molecules and the Paneth and goblet cells, along with the reduction of iNOS and pro-inflammatory cytokines (IL-1beta, TNF-alpha, IL-2 and IL-6, and IL-12). icariin 13-20 tumor necrosis factor Mus musculus 230-239 20686223-2 2010 We found that this icariin derivative inhibits tumor necrosis factor-alpha (TNF-alpha) production, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expression, and protein expression in lipopolysaccharide (LPS) stimulated RAW264.7 macrophages. icariin 19-26 tumor necrosis factor Mus musculus 47-74 20686223-2 2010 We found that this icariin derivative inhibits tumor necrosis factor-alpha (TNF-alpha) production, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expression, and protein expression in lipopolysaccharide (LPS) stimulated RAW264.7 macrophages. icariin 19-26 tumor necrosis factor Mus musculus 76-85 19526759-6 2009 in vivo studies showed that icariin at the dose of 20 mg/kg significantly lowered serum TNF-alpha and IL-6 levels (P < 0.01), reduced the average fluorescence intensity of adhesion molecules CD11b (P < 0.01), and alleviated pulmonary inflammatory cell infiltration. icariin 28-35 tumor necrosis factor Mus musculus 88-97 19526759-7 2009 CONCLUSION: Icariin is a safe and effective natural anti-inflammatory drug, its partial mechanism is possible the multiple links intervention on pro-inflammatory cytokines (TNF-alpha, IL-6), inflammatory mediators (NO) and adhesion molecules (CD11b). icariin 12-19 tumor necrosis factor Mus musculus 173-182 34231485-11 2021 ICA significantly inhibited expressions of IL-6 and TNF-alpha compared to the DSS group (P < .05). icariin 0-3 tumor necrosis factor Mus musculus 52-61 33433547-12 2021 Besides, ICA inhibited the expressions of TLR4, p-NF-kappaB p65, TNF-alpha and IL-6 remarkably in renal tissues. icariin 9-12 tumor necrosis factor Mus musculus 65-74 32871176-5 2020 Furthermore, ICA treatment significantly mitigated the EAE-increased iNOS, TNF-alpha, CD206 and TGF-beta1, but further reduced IL-10 mRNA transcripts in the brain mice. icariin 13-16 tumor necrosis factor Mus musculus 75-84 35149295-8 2022 Evidently, Icariin prevented the neutrophilia/lymphopenia caused by CYP, and markedly improved the antioxidant enzymes level including superoxide dismutase, glutathione sulfo-transferase, catalase, glutathione level and reduced Malondialdehyde level, myeloperoxidase activity and nitric oxide, and also decreased the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in bladder. icariin 11-18 tumor necrosis factor Mus musculus 331-358 35149295-8 2022 Evidently, Icariin prevented the neutrophilia/lymphopenia caused by CYP, and markedly improved the antioxidant enzymes level including superoxide dismutase, glutathione sulfo-transferase, catalase, glutathione level and reduced Malondialdehyde level, myeloperoxidase activity and nitric oxide, and also decreased the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in bladder. icariin 11-18 tumor necrosis factor Mus musculus 360-369