PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26679678-6	2016	It was found that pretreatment with ICA could decrease neurological deficit score, diminish the infarct volume, and reduce the protein levels of IL-1beta and TGF-beta1.	icariin	36-39	interleukin 1 beta	Rattus norvegicus	145-153	
34426999-0	2021	Icariin attenuates renal fibrosis in chronic kidney disease by inhibiting interleukin-1beta/transforming growth factor-beta-mediated activation of renal fibroblasts.	icariin	0-7	interleukin 1 beta	Rattus norvegicus	74-91	
28505603-10	2017	Further, the anti-autophagic property of ICA was evidenced by amelioration of the decrease in mTOR and p70S6 kinase expression and an increase in TLR4, NFkappaB, IL1-beta, and COX-2 immunohistochemically.	icariin	41-44	interleukin 1 beta	Rattus norvegicus	162-170	
25791226-6	2015	Interestingly, icariin negatively regulated the activation of the nod-like receptor protein 3 (NLRP3) inflammasome/caspase-1/IL-1beta axis in the hippocampus of CMS rats.	icariin	15-22	interleukin 1 beta	Rattus norvegicus	125-133	
25647547-5	2015	The results showed that icariin significantly reduced the increase in the mRNA expression of tumor necrosis factor alpha, interleukin (IL)-1beta and IL-6 that occurred in response to LPS.	icariin	24-31	interleukin 1 beta	Rattus norvegicus	122-144	
25791226-7	2015	These results confirm that icariin exerts antidepressant-like effects, which may be mediated, at least in part, by enhanced antioxidant status and anti-inflammatory effects on the brain tissue via the inhibition of NF-kappaB signaling activation and the NLRP3-inflammasome/caspase-1/IL-1beta axis.	icariin	27-34	interleukin 1 beta	Rattus norvegicus	283-291	
20382007-6	2010	In conclusion, this study suggested that icariin can improve spatial learning and memory abilities in rats with brain dysfunction induced by LPS, an effect which may be due to decreased expressions of TNF-alpha, IL-1beta and COX-2 in the hippocampus.	icariin	41-48	interleukin 1 beta	Rattus norvegicus	212-220