PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23158946-11	2012	CONCLUSION: Icariin promotes differentiation of the mesenchymal stem cells C3H10T1/2 into osteoblasts, and its effect is related to the restraining of ERK expression and activation of p38 expression in the MAPK signaling pathway.	icariin	12-19	mitogen-activated protein kinase 14	Mus musculus	184-187	
31432106-11	2019	Furthermore, ICA administration was observed to inhibit p38 activation during cerulein-induced AP.	icariin	13-16	mitogen-activated protein kinase 14	Mus musculus	56-59	
31432106-13	2019	Collectively, our results suggested that ICA exhibits anti-inflammatory effects in cerulein-induced AP via the inhibition of p38.	icariin	41-44	mitogen-activated protein kinase 14	Mus musculus	125-128	
32871176-6	2020	More importantly, ICA treatment significantly mitigated the inflammation-related NF-kappaB, AKT, ERK1/2, p38, c-Jun and MEK phosphorylation in the brain of EAE mice.	icariin	18-21	mitogen-activated protein kinase 14	Mus musculus	105-108	
29245919-0	2017	Icariin induces cell differentiation and cell cycle arrest in mouse melanoma B16 cells via Erk1/2-p38-JNK-dependent pathway.	icariin	0-7	mitogen-activated protein kinase 14	Mus musculus	98-101	
29245919-8	2017	Finally, we found that ICA increased down-regulated the Erk1/2, p-Erk1/2, p38, p-p38, and p-JNK protein levels in B16 cells when compared with the control group.	icariin	23-26	mitogen-activated protein kinase 14	Mus musculus	74-77	
29245919-8	2017	Finally, we found that ICA increased down-regulated the Erk1/2, p-Erk1/2, p38, p-p38, and p-JNK protein levels in B16 cells when compared with the control group.	icariin	23-26	mitogen-activated protein kinase 14	Mus musculus	81-84	
29245919-9	2017	Taken together, these results indicated that ICA could induce B16 cell differentiation and cell cycle arrest at G0/G1 phase through inhibiting Erk1/2-p38-JNK-dependent signaling molecules.	icariin	45-48	mitogen-activated protein kinase 14	Mus musculus	150-153	
23158946-9	2012	Phospho-p42 was decreased after 10-minute icariin treatment, while phospho-p38 expression displayed an increase after 10- and 30-minute of treatment with icariin.	icariin	154-161	mitogen-activated protein kinase 14	Mus musculus	75-78	
18484897-6	2008	Moreover, the inducible effect of icariin was blunted by SB203580, a specific inhibitor of p38MAPK.	icariin	34-41	mitogen-activated protein kinase 14	Mus musculus	91-98	
18484897-0	2008	Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro.	icariin	54-61	mitogen-activated protein kinase 14	Mus musculus	15-22	
18484897-8	2008	Nuclear location of MEF2C, which played a critical role in cardiomyocyte differentiation and could be activated by p38MAPK, was stimulated after icariin exposure.	icariin	145-152	mitogen-activated protein kinase 14	Mus musculus	115-122	
18484897-9	2008	Taken together, these results suggest that ROS generation and the subsequent activation of p38MAPK are essential for the inducible function of icariin on cardiomyocyte differentiation of murine embryonic stem cells in vitro.	icariin	143-150	mitogen-activated protein kinase 14	Mus musculus	91-98	
17883938-5	2007	The phosphorylation of the p38 mitogen-activated protein kinase (MAPK) was studied in the differentiation process, and its specific inhibitor SB203580 was employed to confirm the function of the p38 MAPK on icariin-induced cardiac differentiation.	icariin	207-214	mitogen-activated protein kinase 14	Mus musculus	195-203	
17883938-8	2007	Moreover, the inhibition of the p38 MAPK pathway by SB203580 efficiently abolished icariin-stimulated cardiomyocyte differentiation and resulted in the capture of the upregulation of PGC-1alpha, PPARalpha, and NRF-1.	icariin	83-90	mitogen-activated protein kinase 14	Mus musculus	32-40	
17883938-9	2007	CONCLUSION: Taken together, icariin promoted the expression of PGC-1alpha, PPARalpha, and NRF-1 during cardiomyocyte differentiation of murine ES cells in vitro and the effect was partly responsible for the activation of the p38 MAPK.	icariin	28-35	mitogen-activated protein kinase 14	Mus musculus	225-233	
18423597-7	2008	It could be concluded that p38 and ERK1, 2 are activated in a coordinated manner, which in turn contribute to NF-kappaB and AP-1 activation in icariin induced cardiomyogenic cell lineage differentiation of mouse ES cells.	icariin	143-150	mitogen-activated protein kinase 14	Mus musculus	27-30