PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35149295-8	2022	Evidently, Icariin prevented the neutrophilia/lymphopenia caused by CYP, and markedly improved the antioxidant enzymes level including superoxide dismutase, glutathione sulfo-transferase, catalase, glutathione level and reduced Malondialdehyde level, myeloperoxidase activity and nitric oxide, and also decreased the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in bladder.	icariin	11-18	interleukin 1 beta	Mus musculus	375-393	
24969548-7	2014	ICA also reduced pro-inflammatory cytokine expression of interleukin-1beta and tumor necrosis factor-alpha in RAW264.7 cells cultured with Ti particles.	icariin	0-3	interleukin 1 beta	Mus musculus	57-106	
30146016-12	2018	Finally, icariin suppressed NLRP3 inflammasome activation and IL-1beta production in MRL/lpr mice.	icariin	9-16	interleukin 1 beta	Mus musculus	62-70	
31432106-10	2019	In addition, ICA suppressed the production of pro-inflammatory cytokines, including interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha in the pancreas.	icariin	13-16	interleukin 1 beta	Mus musculus	84-106	
30978648-10	2019	Icariin treatment prominently mitigated the protein expression of proinflammatory factors like nuclear factor-kappaB, cyclooxygenase-2, interleukin 1-beta and prooxidative enzyme (NADPH oxidase-4), and it increased the protein expression of antioxidative enzymes (superoxide dismutase and catalase).	icariin	0-7	interleukin 1 beta	Mus musculus	136-154	
30505282-8	2018	Meanwhile, ICA decreased the production of interleukin-1 beta, tumor necrosis factor-alpha and inducible nitric oxide synthase at 24 h and 3 days after SCI.	icariin	11-14	interleukin 1 beta	Mus musculus	43-90	
25985156-12	2015	In addition, immunohistochemical analysis and enzyme-linked immunosorbent assay showed icariin significantly reduced expression and secretion of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 in the calvariae of titanium-stimulated mice.	icariin	87-94	interleukin 1 beta	Mus musculus	174-191