PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29867480-9	2018	Furthermore, our studies showed that icariin exerted stronger anti-apoptotic effects than genistein and 17beta-estradiol (E2) and inhibited the cleavage of downstream caspase-3 in MC3T3-E1 cells induced by a potent PI3K inhibitor, PI828 (at 2 muM).	icariin	37-44	caspase 3	Mus musculus	167-176	
32671530-8	2021	ICA reversed the HI-induced reduction in phosphorylated Akt and activation of cleaved caspase-3.	icariin	0-3	caspase 3	Mus musculus	86-95	
32885795-9	2020	UA decreased Min6 cell viability, enhanced cell apoptosis and levels of cleaved caspase-3, and reduced pro-caspase3 levels and insulin secretion, with all of these effects reversed by ICA in a dose-dependent manner.	icariin	184-187	caspase 3	Mus musculus	80-89	
32885795-9	2020	UA decreased Min6 cell viability, enhanced cell apoptosis and levels of cleaved caspase-3, and reduced pro-caspase3 levels and insulin secretion, with all of these effects reversed by ICA in a dose-dependent manner.	icariin	184-187	caspase 3	Mus musculus	107-115	
30745820-11	2019	Furthermore, ICA significantly inhibited the expression of ER stress apoptotic proteins caspase-12, CHOP, Bax/Bcl-2, caspase-9 and caspase-3.	icariin	13-16	caspase 3	Mus musculus	131-140	
23764463-3	2013	Here, we found that Icariin could promote MC3T3-E1 osteoblastic cell proliferation and reduce cell apoptosis, associated with increased mRNA levels of positive regulators of cell cycle gene Cyclin E and proliferating cell nuclear antigen (PCNA), decreaed mRNA level of negative regulator gene, Cyclin-dependent kinase 4 inhibitor B (Cdkn2B), and reduced caspase-3 activity.	icariin	20-27	caspase 3	Mus musculus	354-363	
24948525-9	2014	Icariin treatment significantly improved miR-21 expression in all embryo stages, reduced the transcriptional levels of caspase 3 and PTEN, and increased the levels of Bcl-2.	icariin	0-7	caspase 3	Mus musculus	119-128	
34906049-11	2021	Additionally, icariin mitigated the NAFLD-induced up-regulation of the cleaved caspase 3/9, SREBP-1c, and DGAT-2 levels, and enhanced the expression level of CPT-1, p-ACC/ACC, AMPKalpha1, PGC-1alpha, and GLUT4.	icariin	14-21	caspase 3	Mus musculus	79-90