PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32736044-10 2020 Icariin inhibited OC SKOV3 cell proliferation, migration and invasion in vitro and promoted apoptosis by inhibiting the PI3K/AKT signalling pathway. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 125-128 32736044-11 2020 CONCLUSION: Icariin promotes apoptosis and suppresses SKOV3 cell activities through the PI3K-Akt signalling pathway. icariin 12-19 AKT serine/threonine kinase 1 Homo sapiens 93-96 32751124-7 2020 After four weeks in culture, 3D differentiated constructs and 2D monolayer cultures treated with Icariin or Purmorphamine showed increased mineralization, ALP activity, and the gene expression of bone formation markers (BGLAP, SSP1, and COL1A1), signaling molecules (MAPK1, WNT1, and AKT1), and transcription factors (RUNX2 and GLI1) that regulate osteogenic differentiation relative to untreated. icariin 97-104 AKT serine/threonine kinase 1 Homo sapiens 284-288 31785072-10 2019 Apart from this, the activation of PI3K/AKT and Raf1/ERK1/2 signaling pathways was inhibited by ICA through upregulating miR-7 expression. icariin 96-99 AKT serine/threonine kinase 1 Homo sapiens 40-43 31682849-7 2019 Mechanistically, icariin activated the mitochondrial pathway by inhibiting the activation of the PI3K-Akt pathway-associated kinase, Akt, resulting in the activation of members of the caspase family of proteins, and thus inducing apoptosis of A549 cells. icariin 17-24 AKT serine/threonine kinase 1 Homo sapiens 102-105 31682849-7 2019 Mechanistically, icariin activated the mitochondrial pathway by inhibiting the activation of the PI3K-Akt pathway-associated kinase, Akt, resulting in the activation of members of the caspase family of proteins, and thus inducing apoptosis of A549 cells. icariin 17-24 AKT serine/threonine kinase 1 Homo sapiens 133-136 32011040-10 2020 Besides, ICA notably frustrated JAK1/STAT3 and PI3K/AKT activations in DAOY cells. icariin 9-12 AKT serine/threonine kinase 1 Homo sapiens 52-55 32011040-12 2020 The results concluded that ICA exhibited the antitumor activity in DAOY cells via decreasing SPARC and inactivating JAK1/STAT3 and PI3K/AKT pathways. icariin 27-30 AKT serine/threonine kinase 1 Homo sapiens 136-139 31785072-11 2019 The study released that ICA inhibited both BPH-1 and RWPE-1 cells proliferation, migration and promoted apoptosis by upregulating the levels of miR-7 expression, which was related to PI3K/AKT and Raf1/ERK1/2 signaling pathways. icariin 24-27 AKT serine/threonine kinase 1 Homo sapiens 188-191 30873034-9 2019 Further studies showed that icariin attenuated iron overload induced inactivation of the PI3K/AKT/mTOR pathway and activation of the ERK1/2 and JNK pathways. icariin 28-35 AKT serine/threonine kinase 1 Homo sapiens 94-97 31091496-7 2019 The ICA prevented the degradation of GJIC and impairment of Cx43 induced by MC-LR via suppressing the Akt pathway. icariin 4-7 AKT serine/threonine kinase 1 Homo sapiens 102-105 31424652-0 2019 Icariin inhibits the growth of human cervical cancer cells by inducing apoptosis and autophagy by targeting mTOR/PI3K/AKT signalling pathway. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 118-121 31424652-15 2019 Icariin also induced the generation of ROS and diminished the MMP levels in HeLa cells and blocked the mTOR/PI3K/AKT signalling cascade, suggestive of its potent anticancer activity. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 113-116 30873034-0 2019 Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 141-144 31081049-0 2019 Icariin enhances the chemosensitivity of cisplatin-resistant ovarian cancer cells by suppressing autophagy via activation of the AKT/mTOR/ATG5 pathway. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 129-132 31081049-9 2019 At the molecular level, rapamycin treatment or overexpression of ATG5 reversed the effects of icariin on the expression of autophagy-associated proteins, including microtubule-associated protein 1 light chain 3beta, Beclin-1, ATG5 and p62, and the AKT/mammalian target of rapamycin (mTOR) pathway. icariin 94-101 AKT serine/threonine kinase 1 Homo sapiens 248-251 18789310-0 2008 Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 68-71 29767263-0 2018 Icariin promotes wound healing by enhancing the migration and proliferation of keratinocytes via the AKT and ERK signaling pathway. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 101-104 25747987-0 2015 Icariin enhances cytotoxicity of doxorubicin in human multidrug-resistant osteosarcoma cells by inhibition of ABCB1 and down-regulation of the PI3K/Akt pathway. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 148-151 25747987-10 2015 In conclusion, icariin possesses a reversal effect on multidrug resistance in MG-63/DOX cells through down-regulation of the MDR1 and the PI3K/Akt pathway, and has the potential to be an adjunct to chemotherapy for osteosarcoma. icariin 15-22 AKT serine/threonine kinase 1 Homo sapiens 143-146 20416296-1 2010 Icariin, a flavonoid isolated from Epimedii herba, stimulated phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser1177, Akt (Ser473) and ERK1/2 (Thr202/Tyr204). icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 134-137 20416296-6 2010 PI3K/Akt and MAPK-ERK kinase (MEK)/ERK1/2 pathways were involved in the phosphorylation of eNOS by icariin. icariin 99-106 AKT serine/threonine kinase 1 Homo sapiens 5-8 30551489-0 2019 Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 120-123 30551489-8 2019 Importantly, LY294002, a specific PI3K inhibitor, abrogated the anti-apoptosis effect of icariin, implicating the involvement of PI3K/Akt pathway. icariin 89-96 AKT serine/threonine kinase 1 Homo sapiens 134-137 30551489-9 2019 In summary, icariin prevents cisplatin-induced HEK-293 cell injury by inhibiting oxidative stress, inflammatory response, and cellular apoptosis partly via regulating NF-kappaB and PI3K/Akt signaling pathways. icariin 12-19 AKT serine/threonine kinase 1 Homo sapiens 186-189 30551506-11 2019 Furthermore, ICA inactivated PI3K/AKT and MEK/ERK signaling pathways by mediating miR-625-3p in SW579 and TPC1 cells. icariin 13-16 AKT serine/threonine kinase 1 Homo sapiens 34-37 29767263-3 2018 Using in vitro experiments, it was demonstrated that icariin significantly promoted the migration and proliferation of keratinocytes via the activation of AKT serine/threonine kinase 1 (AKT) and extracellular signal-regulated kinase (ERK). icariin 53-60 AKT serine/threonine kinase 1 Homo sapiens 155-184 29767263-3 2018 Using in vitro experiments, it was demonstrated that icariin significantly promoted the migration and proliferation of keratinocytes via the activation of AKT serine/threonine kinase 1 (AKT) and extracellular signal-regulated kinase (ERK). icariin 53-60 AKT serine/threonine kinase 1 Homo sapiens 155-158 29767263-4 2018 Inhibition of AKT or ERK reversed the effects of icariin on the proliferation and migration of keratinocytes. icariin 49-56 AKT serine/threonine kinase 1 Homo sapiens 14-17 29767263-7 2018 The present findings revealed that icariin may be a promising drug to promote the migration and proliferation of keratinocytes, and to accelerate the healing of skin wounds, through its role in the upregulation of AKT and ERK signaling. icariin 35-42 AKT serine/threonine kinase 1 Homo sapiens 214-217 28667862-0 2017 Icariin exerts inhibitory effects on the growth and metastasis of KYSE70 human esophageal carcinoma cells via PI3K/AKT and STAT3 pathways. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 115-118 29259641-0 2017 Icariin Prevents IL-1beta-Induced Apoptosis in Human Nucleus Pulposus via the PI3K/AKT Pathway. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 83-86 29259641-7 2017 When the PI3K/AKT pathway was blocked by LY294002, a specific inhibitor of this pathway, the protective effect of icariin was impaired. icariin 114-121 AKT serine/threonine kinase 1 Homo sapiens 14-17 29259641-8 2017 In summary, icariin might be a protective traditional Chinese medicine, which prevents inflammation-induced degeneration of intervertebral discs partly through the PI3K/AKT pathway. icariin 12-19 AKT serine/threonine kinase 1 Homo sapiens 169-172 27545131-0 2016 [Icariin reduces S-nitrosogultathione induced endothelial cell apoptosis through modulating AKT/P53 pathway]. icariin 1-8 AKT serine/threonine kinase 1 Homo sapiens 92-95 27545131-12 2016 (6) The expression of AKT/p-AKT was significantly lower in GSNO group than in the blank control group (P< 0.05), which could be significantly upregulated by pretreatment with high, medium and low concentration ICA in a concentration-dependent manner, above effects could be blocked by LY294002 (all P<0.05). icariin 213-216 AKT serine/threonine kinase 1 Homo sapiens 22-25 27545131-12 2016 (6) The expression of AKT/p-AKT was significantly lower in GSNO group than in the blank control group (P< 0.05), which could be significantly upregulated by pretreatment with high, medium and low concentration ICA in a concentration-dependent manner, above effects could be blocked by LY294002 (all P<0.05). icariin 213-216 AKT serine/threonine kinase 1 Homo sapiens 28-31 27545131-16 2016 CONCLUSION: Icariin could reduce GSNO induced endothelial cell apoptosis through activating AKT pathway and downregulating P53 activity. icariin 12-19 AKT serine/threonine kinase 1 Homo sapiens 92-95 22088582-4 2011 It was found that icariin has been closely highlighted in the intervention of p38 mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt signal pathways, inhibition of phosphodiesterase 5, and regulation of nuclear receptors. icariin 18-25 AKT serine/threonine kinase 1 Homo sapiens 150-153 18789310-7 2008 These results suggest that icariin stimulated angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways and may be a useful drug for angiogenic therapy. icariin 27-34 AKT serine/threonine kinase 1 Homo sapiens 95-98 18789310-3 2008 Icariin activated the angiogenic signal modulators, ERK, phosphatidylinositol 3-kinase (PI3K), Akt, and endothelial nitric oxide synthase (eNOS), and increased NO production, without affecting VEGF expression, indicating that icariin may directly stimulate angiogenesis. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 95-98 35514319-0 2022 Icariin inhibits the malignant progression of lung cancer by affecting the PI3K/Akt pathway through the miR-205-5p/PTEN axis. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 80-83 34147477-6 2021 Under basal conditions of astrocytes, icariin and icaritin treatment alone increased the phosphorylation of ERK1/2 and AKT, which could be blocked by JB-1. icariin 38-45 AKT serine/threonine kinase 1 Homo sapiens 119-122 34306206-0 2021 Icariin inhibits oral squamous cell carcinoma cell proliferation and induces apoptosis via inhibiting the NF-kappaB and PI3K/AKT pathways. icariin 0-7 AKT serine/threonine kinase 1 Homo sapiens 125-128 34306206-11 2021 The protein expression levels of phosphorylated (p)-p65, p-PI3K and p-AKT were decreased in OSCC cells treated with ICA. icariin 116-119 AKT serine/threonine kinase 1 Homo sapiens 70-73 34306206-12 2021 The aforementioned findings revealed that ICA could attenuate the proliferation of OSCC cells and induce apoptosis via inhibiting the NF-kappaB and PI3K/AKT signaling pathways. icariin 42-45 AKT serine/threonine kinase 1 Homo sapiens 153-156 35514319-9 2022 Importantly, rescue experiment results showed that ICA could target the miR-205-5p/PTEN axis to affect the PI3K/Akt signaling, thereby suppressing the malignant cell phenotype of lung cancer. icariin 51-54 AKT serine/threonine kinase 1 Homo sapiens 112-115 35114909-0 2022 Proapoptotic Effect of Icariin on Human Ovarian Cancer Cells via the NF-(Formula: see text)B/PI3K-AKT Signaling Pathway: A Network Pharmacology-Directed Experimental Investigation. icariin 23-30 AKT serine/threonine kinase 1 Homo sapiens 98-101 35442463-17 2022 CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD. icariin 17-24 AKT serine/threonine kinase 1 Homo sapiens 219-222