PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34657986-7 2021 Moreover, ICA-loaded mPEG-ICA nanoparticles significantly decreased the mRNA expression of the myocardial inflammatory cytokines TNF-alpha, IL-1beta and IL-6M. icariin 10-13 tumor necrosis factor Rattus norvegicus 129-138 34657986-7 2021 Moreover, ICA-loaded mPEG-ICA nanoparticles significantly decreased the mRNA expression of the myocardial inflammatory cytokines TNF-alpha, IL-1beta and IL-6M. icariin 26-29 tumor necrosis factor Rattus norvegicus 129-138 29950992-9 2018 The negative effects of TNF-alpha on chondrocytes can be partially blocked by treating with icariin or ammonium pyrrolidinedithiocarbamate (PDTC, an NF-kappaB inhibitor). icariin 92-99 tumor necrosis factor Rattus norvegicus 24-33 34565677-8 2022 Upregulation of IL-10 and decreased expressions of NF-kappaB and TNF-alpha were revealed in western blots, indicating an anti-inflammatory effect of icariin. icariin 149-156 tumor necrosis factor Rattus norvegicus 65-74 31432160-12 2019 In addition, icariin alleviated oxidative stress in SCI rats and decreased the levels of inflammatory molecules, including interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, nitric oxide, nuclear factor-kappaB and inducible nitric oxide synthase, and increased the expression of anti-inflammatory proteins, including NADPH-quinone oxidoreductase-1, heme oxygenase-1 and nuclear factor erythroid 2-related factor 2 in the injured spinal cord. icariin 13-20 tumor necrosis factor Rattus norvegicus 153-180 29950992-10 2018 The present study data also suggested that icariin suppressed both TNF-alpha-stimulated p65 nuclear translocation and IkappaBalpha protein degradation. icariin 43-50 tumor necrosis factor Rattus norvegicus 67-76 25724443-3 2015 In in vivo rat model of myocardial ischemia/reperfusion, we found that postconditioning with icariin significantly reduced myocardial infarct size, serum level of TNF-alpha and IL-10, TNF-alpha and IL-10 expression, and apoptosis. icariin 93-100 tumor necrosis factor Rattus norvegicus 163-172 25724443-3 2015 In in vivo rat model of myocardial ischemia/reperfusion, we found that postconditioning with icariin significantly reduced myocardial infarct size, serum level of TNF-alpha and IL-10, TNF-alpha and IL-10 expression, and apoptosis. icariin 93-100 tumor necrosis factor Rattus norvegicus 184-193 20382007-6 2010 In conclusion, this study suggested that icariin can improve spatial learning and memory abilities in rats with brain dysfunction induced by LPS, an effect which may be due to decreased expressions of TNF-alpha, IL-1beta and COX-2 in the hippocampus. icariin 41-48 tumor necrosis factor Rattus norvegicus 201-210 25647547-5 2015 The results showed that icariin significantly reduced the increase in the mRNA expression of tumor necrosis factor alpha, interleukin (IL)-1beta and IL-6 that occurred in response to LPS. icariin 24-31 tumor necrosis factor Rattus norvegicus 93-120