PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22201948-6 2012 ICA promoted bMSCs diffenentiation from CORT rat, and increased the secretion of osteocalcin, collagen I, runt-related transcription factor 2 in OVX model. icariin 0-3 bone gamma-carboxyglutamate protein Rattus norvegicus 81-92 26380448-12 2015 (2) When Icariin promoted osteogenic differentiation of BMSCs, Runx2 mRNA expression levels and ALP activities increased earlier and then decreased, while osteocalcin mRNA expression levels continued to increase (P < 0.01). icariin 9-16 bone gamma-carboxyglutamate protein Rattus norvegicus 155-166 32262676-6 2015 The in vitro results showed that icariin significantly improved osteogenic differentiation of rat BMSCs demonstrated by the enhanced alkaline phosphatase (ALP) activity and gene expression of runt-related transcription factor-2 (Runx2), ALP, collagen type I (Col I), osteocalcin (OCN) and OCN protein secretion. icariin 33-40 bone gamma-carboxyglutamate protein Rattus norvegicus 267-278 32262676-6 2015 The in vitro results showed that icariin significantly improved osteogenic differentiation of rat BMSCs demonstrated by the enhanced alkaline phosphatase (ALP) activity and gene expression of runt-related transcription factor-2 (Runx2), ALP, collagen type I (Col I), osteocalcin (OCN) and OCN protein secretion. icariin 33-40 bone gamma-carboxyglutamate protein Rattus norvegicus 280-283 32262676-6 2015 The in vitro results showed that icariin significantly improved osteogenic differentiation of rat BMSCs demonstrated by the enhanced alkaline phosphatase (ALP) activity and gene expression of runt-related transcription factor-2 (Runx2), ALP, collagen type I (Col I), osteocalcin (OCN) and OCN protein secretion. icariin 33-40 bone gamma-carboxyglutamate protein Rattus norvegicus 289-292 24183044-11 2013 The ICA group also had significantly higher serum levels of osteocalcin (P<0.05) and lower level of anti-tartaric acid phosphatase 5b(P<0.05). icariin 4-7 bone gamma-carboxyglutamate protein Rattus norvegicus 60-71 28681147-9 2018 Icariin combined with stem cells significantly reduced body weight gain caused by ovariectomy, significantly decreased alkaline phosphatase, tartrate-resistant acid phosphatase, and bone gamma-carboxyglutamate protein content in serum, significantly increased osteoprotegerin content, significantly elevated bone mineral density of the lumbar spine, left femur, and right femur, and enhanced bone biomechanical properties of the femur, including maximum bending load, bending rigidity, and fracture energy, in osteoporotic rats. icariin 0-7 bone gamma-carboxyglutamate protein Rattus norvegicus 182-217 16751992-8 2006 (2) Icariin treatment also improved the steady-state serum BGP and might have promoted bone formation. icariin 4-11 bone gamma-carboxyglutamate protein Rattus norvegicus 59-62 32525771-7 2020 In addition, Icariin increased the serum levels of osteocalcin (OC), bone-specific alkaline phosphatase (BAP), N-terminal telopeptides of type I collagen (NTX-1), C-terminal telopeptide of type I collagen (CTX-1) and tartrate-resistant acid phosphatase 5b (TRACP-5b); promoted osteocalcin secretion at the fracture site; and accelerated fracture healing. icariin 13-20 bone gamma-carboxyglutamate protein Rattus norvegicus 51-62 32525771-7 2020 In addition, Icariin increased the serum levels of osteocalcin (OC), bone-specific alkaline phosphatase (BAP), N-terminal telopeptides of type I collagen (NTX-1), C-terminal telopeptide of type I collagen (CTX-1) and tartrate-resistant acid phosphatase 5b (TRACP-5b); promoted osteocalcin secretion at the fracture site; and accelerated fracture healing. icariin 13-20 bone gamma-carboxyglutamate protein Rattus norvegicus 277-288 31943455-10 2020 Mechanistically, icariin-promoted transcription of the downstream osteogenic gene osteocalcin (Ocn) through STAT3 and STAT3 bound to the promoter of Ocn. icariin 17-24 bone gamma-carboxyglutamate protein Rattus norvegicus 95-98 31943455-10 2020 Mechanistically, icariin-promoted transcription of the downstream osteogenic gene osteocalcin (Ocn) through STAT3 and STAT3 bound to the promoter of Ocn. icariin 17-24 bone gamma-carboxyglutamate protein Rattus norvegicus 149-152 27347050-9 2016 Treatment with ICA also completely normalized the expression of osteoblast markers by increasing serum concentrations of OPG and BGP. icariin 15-18 bone gamma-carboxyglutamate protein Rattus norvegicus 129-132 29208188-8 2017 The results demonstrated that ovariectomized rats treated with icariin had significantly higher bone mineral density (femur and lumbar spine) and lower bone turnover markers (serum alkaline phosphatase and osteocalcin) compared with the ovariectomized control group. icariin 63-70 bone gamma-carboxyglutamate protein Rattus norvegicus 206-217 28486190-4 2017 Icariin (0.1muM) upregulated TAZ, Runx2, beta-catenin, Osteopotin, and Dlx5 expression mainly at the early stage of osteogenic differentiation, and increased osteocalcin expression at the late stage. icariin 0-7 bone gamma-carboxyglutamate protein Rattus norvegicus 158-169 27764755-6 2016 Additionally, icariin (0.1muM) significantly up-regulated the expression of osteogenic genes (Runx2, osteopotin, DLX5, osteocalcin, collagen type I, and ERalpha) and Wnt signal members (beta-catenin, Lef1, TCF7, c-jun, c-myc, and cyclin D). icariin 14-21 bone gamma-carboxyglutamate protein Rattus norvegicus 119-130 27721833-4 2016 In in vitro cellular experiments, icariin at optimal concentration (10-6 mol/L) could significantly upregulate the osteogenesis- and angiogenesis-related genes and proteins, such as Runx2, ALP, osteocalcin, vascular endothelial growth factors, and fibroblast growth factors, as well as the mineralization of BMSCs. icariin 34-41 bone gamma-carboxyglutamate protein Rattus norvegicus 194-205