PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30155911-3	2019	AIM: To explore the immunomodulation of icariin on cutaneous HPAA by detecting the response to the inflammatory cytokines tumour necrosis factor-alpha/interferon-gamma in HaCaT cells.	icariin	40-47	interferon gamma	Homo sapiens	151-167	
26507164-9	2015	Icariin treatment resulted in a reduced expression of p-P38 and p-ERK signal activation induced by TNF-alpha/IFN-gamma; however, only SB203580, the p38 alpha/beta inhibitor, inhibited the secretion of inflammatory cytokines induced by TNF-alpha/IFN-gamma in cultured HaCaT cells.	icariin	0-7	interferon gamma	Homo sapiens	109-118	
26507164-9	2015	Icariin treatment resulted in a reduced expression of p-P38 and p-ERK signal activation induced by TNF-alpha/IFN-gamma; however, only SB203580, the p38 alpha/beta inhibitor, inhibited the secretion of inflammatory cytokines induced by TNF-alpha/IFN-gamma in cultured HaCaT cells.	icariin	0-7	interferon gamma	Homo sapiens	245-254	
26507164-10	2015	The differential expression of TNF-alpha-R1 and IFN-gamma-R1 was also observed after the stimulation of TNF-alpha/IFN-gamma, which was significantly normalized after the icariin treatment.	icariin	170-177	interferon gamma	Homo sapiens	48-57	
26507164-0	2015	Icariin inhibits TNF-alpha/IFN-gamma induced inflammatory response via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes.	icariin	0-7	interferon gamma	Homo sapiens	27-36	
26507164-3	2015	In this study, we evaluated the anti-inflammatory potential and mechanisms of icariin in the tumor necrosis factor-alpha (TNF-alpha)/interferon-gamma (IFN-gamma)-induced inflammatory response in human keratinocytes (HaCaT cells) by observing these cells in the presence or absence of icariin.	icariin	78-85	interferon gamma	Homo sapiens	133-160	
26507164-8	2015	We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner.	icariin	14-21	interferon gamma	Homo sapiens	42-51	
26507164-8	2015	We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner.	icariin	146-153	interferon gamma	Homo sapiens	42-51