PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24550686-1	2014	OBJECTIVE: The purpose of this study was to investigate the effects and pharmacological mechanisms of icariin, which is the main component in the traditional Chinese herb Epimedium, on beta-amyloid (Abeta) production in an amyloid precursor protein (APP) transgenic (Tg) mouse model of Alzheimer"s disease (AD).	icariin	102-109	amyloid beta (A4) precursor protein	Mus musculus	185-205	
26584824-4	2016	RESULTS: Icariin significantly improved spatial learning and memory retention in 3 x Tg-AD mice, promoted neuronal cell activity as identified by the enhancement of brain metabolite N-acetylaspartate level and ATP production in AD mice, preserved the expressions of mitochondrial key enzymes COX IV, PDHE1alpha, and synaptic protein PSD95, reduced Abeta plaque deposition in the cortex and hippocampus of AD mice, and inhibited beta-site APP cleavage enzyme 1 (BACE1) expression.	icariin	9-16	amyloid beta (A4) precursor protein	Mus musculus	348-353	
26584824-5	2016	Icariin treatment also decreased the levels of extracellular and intracellular Abeta1-42 in 3 x Tg-AD primary neurons, modulated the distribution of Abeta along the neurites, and protected against mitochondrial fragmentation in 3 x Tg-AD neurons.	icariin	0-7	amyloid beta (A4) precursor protein	Mus musculus	79-84	
26079110-0	2015	Icariin decreases both APP and Abeta levels and increases neurogenesis in the brain of Tg2576 mice.	icariin	0-7	amyloid beta (A4) precursor protein	Mus musculus	31-36	
26079110-3	2015	This study aims to investigate the effect of icariin on the expression of amyloid precursor protein (APP) and the level of amyloid-beta peptide (Abeta), as well as neurogenesis in the brain of Tg2576 mice, an animal model of Alzheimer"s disease (AD).	icariin	45-52	amyloid beta (A4) precursor protein	Mus musculus	74-99	
26079110-3	2015	This study aims to investigate the effect of icariin on the expression of amyloid precursor protein (APP) and the level of amyloid-beta peptide (Abeta), as well as neurogenesis in the brain of Tg2576 mice, an animal model of Alzheimer"s disease (AD).	icariin	45-52	amyloid beta (A4) precursor protein	Mus musculus	145-150	
26079110-9	2015	The current study demonstrated that icariin improved memory function, decreased the levels of Abeta and APP in the brain, and enhanced neurogenesis in the hippocampus of Tg2576 mice.	icariin	36-43	amyloid beta (A4) precursor protein	Mus musculus	94-99	
24550686-1	2014	OBJECTIVE: The purpose of this study was to investigate the effects and pharmacological mechanisms of icariin, which is the main component in the traditional Chinese herb Epimedium, on beta-amyloid (Abeta) production in an amyloid precursor protein (APP) transgenic (Tg) mouse model of Alzheimer"s disease (AD).	icariin	102-109	amyloid beta (A4) precursor protein	Mus musculus	223-248