PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31772646-0 2019 Icariin reduces high glucose-induced endothelial progenitor cell dysfunction via inhibiting the p38/CREB pathway and activating the Akt/eNOS/NO pathway. icariin 0-7 mitogen activated protein kinase 14 Rattus norvegicus 96-99 31772646-8 2019 Furthermore, icariin significantly suppressed HG-induced p38 and cAMP response element binding protein (CREB) phosphorylation in EPCs (FC: 1.84+-0.21, P=0.0238 vs. HG group for p38; FC: 2.24+-0.15, P=0.0068 vs. HG group for CREB). icariin 13-20 mitogen activated protein kinase 14 Rattus norvegicus 57-60 31772646-8 2019 Furthermore, icariin significantly suppressed HG-induced p38 and cAMP response element binding protein (CREB) phosphorylation in EPCs (FC: 1.84+-0.21, P=0.0238 vs. HG group for p38; FC: 2.24+-0.15, P=0.0068 vs. HG group for CREB). icariin 13-20 mitogen activated protein kinase 14 Rattus norvegicus 177-180 31772646-10 2019 In conclusion, icariin attenuated HG-induced EPC dysfunction, which may be partially attributed to the inhibition of the p38/CREB pathway and the activation of the Akt/eNOS/NO pathway. icariin 15-22 mitogen activated protein kinase 14 Rattus norvegicus 121-124 26307750-0 2016 Icariin Attenuates High-cholesterol Diet Induced Atherosclerosis in Rats by Inhibition of Inflammatory Response and p38 MAPK Signaling Pathway. icariin 0-7 mitogen activated protein kinase 14 Rattus norvegicus 116-119 26307750-13 2016 In conclusion, the present study indicated that icariin inhibited the HCD-induced dyslipidemia in rats, the mechanisms may be associated with the anti-inflammation, anti-oxidative stress, and downregulation of p-p38 MAPK by icariin. icariin 48-55 mitogen activated protein kinase 14 Rattus norvegicus 212-215 25867119-7 2015 It was demonstrated that icariin rapidly phosphorylated extracellular signal-regulated kinase (ERK), p38 kinase and c-Jun N terminal kinase (JNK). icariin 25-32 mitogen activated protein kinase 14 Rattus norvegicus 101-104 25867119-8 2015 Furthermore, icariin-stimulated osteogenic effects on BMSCs were dramatically attenuated by treatment with either specific ERK inhibitor of PD98059, p38 inhibitor of SB202190 or JNK inhibitor SP600125. icariin 13-20 mitogen activated protein kinase 14 Rattus norvegicus 149-152 24940396-8 2014 Phosphorylation of c-Jun N-terminal kinase (JNK) and p38 in Ang II-treated H9c2 cells was blocked by icariin. icariin 101-108 mitogen activated protein kinase 14 Rattus norvegicus 53-56 26221250-0 2015 Icariin stimulates the proliferation of rat bone mesenchymal stem cells via ERK and p38 MAPK signaling. icariin 0-7 mitogen activated protein kinase 14 Rattus norvegicus 84-87 26221250-7 2015 Our work reveals that ICA induces an obvious phosphorylation of ERK and p38 kinases in BMSCs, no matter serum exists or not. icariin 22-25 mitogen activated protein kinase 14 Rattus norvegicus 72-75 26221250-8 2015 Inhibition of ERK or p38 MAPK signaling by their specific inhibitors PD98059 or SP600125, respectively, not only prevents the activation of these kinases, but also attenuates cell proliferation induced by ICA. icariin 205-208 mitogen activated protein kinase 14 Rattus norvegicus 21-24 26221250-10 2015 Taken together, our results demonstrate that ICA promotes the proliferation of rat BMSCs through activating ERK and p38 MAPK signaling which further leads to upregulation of their downstream transcription factors Elk1 and c-Myc. icariin 45-48 mitogen activated protein kinase 14 Rattus norvegicus 116-119 24940396-0 2014 Icariin attenuates angiotensin II-induced hypertrophy and apoptosis in H9c2 cardiomyocytes by inhibiting reactive oxygen species-dependent JNK and p38 pathways. icariin 0-7 mitogen activated protein kinase 14 Rattus norvegicus 147-150 24940396-9 2014 Therefore, the results of the present study indicated that icariin protected H9c2 cardiomyocytes from Ang II-induced hypertrophy and apoptosis by inhibiting the ROS-dependent JNK and p38 pathways. icariin 59-66 mitogen activated protein kinase 14 Rattus norvegicus 183-186 35169865-0 2022 Icariin attenuates thioacetamide-induced bone loss via the RANKL-p38/ERK-NFAT signaling pathway. icariin 0-7 mitogen activated protein kinase 14 Rattus norvegicus 65-68 21182828-9 2011 Taken together, the present results suggest that the protective effects of icariin on apoptosis in hippocampal neuronal cells are potentially mediated through blockade of p38 MAPK phosphorylation. icariin 75-82 mitogen activated protein kinase 14 Rattus norvegicus 171-174 34708631-6 2021 CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway. icariin 83-90 mitogen activated protein kinase 14 Rattus norvegicus 173-176 34708631-6 2021 CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway. icariin 83-90 mitogen activated protein kinase 14 Rattus norvegicus 188-191 35169865-11 2022 In addition, ICA inhibited the protein expression of receptor activator of nuclear factor kappa-Beta ligand (RANKL), receptor activator of nuclear factor kappa-B (RANK), p38, ERK, c-Fos and nuclear factor of activated T cells 1 (NFATc1) in the femur of rats treated with TAA. icariin 13-16 mitogen activated protein kinase 14 Rattus norvegicus 170-173 35169865-12 2022 The results suggested that ICA may inhibit osteoclast differentiation by downregulating the RANKL-p38/ERK-NFAT signaling pathway and prevent TAA-induced bone loss. icariin 27-30 mitogen activated protein kinase 14 Rattus norvegicus 98-101