PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28619001-13	2018	Finally, icariin suppressed IL-1beta-induced activation of MAPK- and NF-kappaB-related signaling pathways.	icariin	9-16	nuclear factor kappa B subunit 1	Homo sapiens	69-78	
34306206-0	2021	Icariin inhibits oral squamous cell carcinoma cell proliferation and induces apoptosis via inhibiting the NF-kappaB and PI3K/AKT pathways.	icariin	0-7	nuclear factor kappa B subunit 1	Homo sapiens	106-115	
34306206-12	2021	The aforementioned findings revealed that ICA could attenuate the proliferation of OSCC cells and induce apoptosis via inhibiting the NF-kappaB and PI3K/AKT signaling pathways.	icariin	42-45	nuclear factor kappa B subunit 1	Homo sapiens	134-143	
33000191-8	2020	Taken together, the results of the present study suggest that the anti-aging molecular mechanisms of ICA may be associated with the regulation of the SIRT1/NF-kappaB pathway.	icariin	101-104	nuclear factor kappa B subunit 1	Homo sapiens	156-165	
33849528-0	2021	Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-kappaB and Wnt/beta-catenin pathways.	icariin	13-20	nuclear factor kappa B subunit 1	Homo sapiens	124-133	
33849528-11	2021	For the part of mechanism exploration, we showed that ICA inhibits the inflammation, proliferation, migration, and invasion, as well as promotes apoptosis and immunity in cervical cancer through impairment of TLR4/MyD88/NF-kappaB and Wnt/beta-catenin pathways.	icariin	54-57	nuclear factor kappa B subunit 1	Homo sapiens	220-229	
30466615-9	2018	Also, icariin blocked the osteoclastogenesis induced by MCF7 and MDA-MB-231 breast cancer cells through inhibition of NF-kappaB activation.	icariin	6-13	nuclear factor kappa B subunit 1	Homo sapiens	118-127	
25688369-1	2015	The aim of the study was to investigate the effect of icariin (ICA) on cardiac aging through its effects on the SIRT6 enzyme and on the NF-kappaB pathway.	icariin	54-61	nuclear factor kappa B subunit 1	Homo sapiens	136-145	
25688369-1	2015	The aim of the study was to investigate the effect of icariin (ICA) on cardiac aging through its effects on the SIRT6 enzyme and on the NF-kappaB pathway.	icariin	63-66	nuclear factor kappa B subunit 1	Homo sapiens	136-145	
25688369-3	2015	Western analysis showed that ICA upregulated SIRT6 protein expression and downregulated NF-kappaB (p65) protein expression in animal tissues and cell models.	icariin	29-32	nuclear factor kappa B subunit 1	Homo sapiens	88-97	
25688369-4	2015	ICA upregulated the expression of SIRT6 and had an inhibitory effect on NF-kappaB inflammatory signaling pathways as shown by decreasing mRNA levels of the NF-kappaB downstream target genes TNF-alpha, ICAM-1, IL-2, and IL-6.	icariin	0-3	nuclear factor kappa B subunit 1	Homo sapiens	72-81	
25688369-4	2015	ICA upregulated the expression of SIRT6 and had an inhibitory effect on NF-kappaB inflammatory signaling pathways as shown by decreasing mRNA levels of the NF-kappaB downstream target genes TNF-alpha, ICAM-1, IL-2, and IL-6.	icariin	0-3	nuclear factor kappa B subunit 1	Homo sapiens	156-165	
25688369-6	2015	We provided evidence that inflammaging may involve a novel link between the effects of ICA on SIRT6 (a regulator of aging) and NF-kappaB (a regulator of inflammation).	icariin	87-90	nuclear factor kappa B subunit 1	Homo sapiens	127-136	
24435883-0	2014	Icariin-mediated inhibition of NF-kappaB activity enhances the in vitro and in vivo antitumour effect of 5-fluorouracil in colorectal cancer.	icariin	0-7	nuclear factor kappa B subunit 1	Homo sapiens	31-40	
24435883-10	2014	The antitumour activity of icariin and its potentiating effect on the antitumour activity of 5-FU implicated the suppression of NF-kappaB activity and consequent down-regulation of the gene products regulated by NF-kappaB.	icariin	27-34	nuclear factor kappa B subunit 1	Homo sapiens	128-137	
24435883-10	2014	The antitumour activity of icariin and its potentiating effect on the antitumour activity of 5-FU implicated the suppression of NF-kappaB activity and consequent down-regulation of the gene products regulated by NF-kappaB.	icariin	27-34	nuclear factor kappa B subunit 1	Homo sapiens	212-221	
24435883-11	2014	Our results showed that icariin, suppressed tumour growth and enhanced the antitumour activity of 5-FU in CRC by inhibiting NF-kappaB activity.	icariin	24-31	nuclear factor kappa B subunit 1	Homo sapiens	124-133