PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23524143-0	2013	mGluR5 stimulating Homer-PIKE formation initiates icariin induced cardiomyogenesis of mouse embryonic stem cells by activating reactive oxygen species.	icariin	50-57	glutamate receptor, ionotropic, kainate 1	Mus musculus	0-6	
23524143-3	2013	Our results showed that the co-expression of mGluR5 together with alpha-actinin or Troponin T in embryoid bodies (EBs) treated with ICA was elevated to 10.86% and 9.62%, compared with the case in the control (4.04% and 3.45%, respectively).	icariin	132-135	glutamate receptor, ionotropic, kainate 1	Mus musculus	45-51	
23524143-4	2013	Exposure of EBs to ICA for 2 h remarkably increased the dimeric form of mGluR5, which was inhibited by small interfering RNA targeting mGluR5 (si-mGluR5).	icariin	19-22	glutamate receptor, ionotropic, kainate 1	Mus musculus	72-78	
23524143-4	2013	Exposure of EBs to ICA for 2 h remarkably increased the dimeric form of mGluR5, which was inhibited by small interfering RNA targeting mGluR5 (si-mGluR5).	icariin	19-22	glutamate receptor, ionotropic, kainate 1	Mus musculus	135-141	
23524143-4	2013	Exposure of EBs to ICA for 2 h remarkably increased the dimeric form of mGluR5, which was inhibited by small interfering RNA targeting mGluR5 (si-mGluR5).	icariin	19-22	glutamate receptor, ionotropic, kainate 1	Mus musculus	135-141	
23524143-6	2013	Furthermore, the activation of mGluR5 by ICA triggered the formation of Homer-PIKE complex and activated PI3K, stimulating ROS generation and NF-kappaB nuclear translocation.	icariin	41-44	glutamate receptor, ionotropic, kainate 1	Mus musculus	31-37	
23524143-7	2013	Knockdown of mGluR5 or inhibition of PI3K by LY294002 blocked ICA induced cardiomyogenesis via repressing mGluR5 pathway, reducing ROS and NF-kappaB activation.	icariin	62-65	glutamate receptor, ionotropic, kainate 1	Mus musculus	13-19	
23524143-7	2013	Knockdown of mGluR5 or inhibition of PI3K by LY294002 blocked ICA induced cardiomyogenesis via repressing mGluR5 pathway, reducing ROS and NF-kappaB activation.	icariin	62-65	glutamate receptor, ionotropic, kainate 1	Mus musculus	106-112	
23524143-8	2013	These results revealed that the inducible mechanisms of ICA were related to activate mGluR5 pathway.	icariin	56-59	glutamate receptor, ionotropic, kainate 1	Mus musculus	85-91