PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29867480-8	2018	Confocal imaging studies confirmed that the phosphorylation of ERalpha at Ser 118 and Ser 167 by genistein and icariin in MC3T3-E1 cells was mediated via MAPK- and PI3K-dependent pathway, respectively.	icariin	111-118	estrogen receptor 1 (alpha)	Mus musculus	63-70	
32528279-8	2020	Parallel in vitro studies also demonstrated that icariin inhibited untoward effects on the TM4 mouse Sertoli cell line with concomitant upregulation of ERalpha and Nrf2 signaling.	icariin	49-56	estrogen receptor 1 (alpha)	Mus musculus	152-159	
32528279-9	2020	Conversely, ERalpha siRNA reversed icariin-mediated protection of Sertoli cell injury.	icariin	35-42	estrogen receptor 1 (alpha)	Mus musculus	12-19	
32528279-10	2020	Our data suggest that icariin effectively ameliorates age-related degeneration of testicular function by alleviating Sertoli cell injury via the ERalpha/Nrf2 signal-transduction pathway.	icariin	22-29	estrogen receptor 1 (alpha)	Mus musculus	145-152	
34803690-0	2021	Icariin Alleviates Wear Particle-Induced Periprosthetic Osteolysis via Down-Regulation of the Estrogen Receptor alpha-mediated NF-kappaB Signaling Pathway in Macrophages.	icariin	0-7	estrogen receptor 1 (alpha)	Mus musculus	94-117	
34803690-7	2021	The effects of icariin on wear particle-induced expression of proinflammatory factors, NF-kappaB signaling modulation, osteolysis, and estrogen receptor alpha (ERalpha) activation were evaluated in vitro and in vivo using bone marrow-derived macrophages and C57/BL6J mice, respectively.	icariin	15-22	estrogen receptor 1 (alpha)	Mus musculus	135-158	
34803690-7	2021	The effects of icariin on wear particle-induced expression of proinflammatory factors, NF-kappaB signaling modulation, osteolysis, and estrogen receptor alpha (ERalpha) activation were evaluated in vitro and in vivo using bone marrow-derived macrophages and C57/BL6J mice, respectively.	icariin	15-22	estrogen receptor 1 (alpha)	Mus musculus	160-167	
34803690-8	2021	A possible link between ERalpha and the protective effect of icariin was further studied using an ERalpha antagonist and the ERalpha-siRNA interference.	icariin	61-68	estrogen receptor 1 (alpha)	Mus musculus	24-31	
34803690-8	2021	A possible link between ERalpha and the protective effect of icariin was further studied using an ERalpha antagonist and the ERalpha-siRNA interference.	icariin	61-68	estrogen receptor 1 (alpha)	Mus musculus	125-132	
34803690-14	2021	The protective effects of icariin on CoCrMo particle-induced mouse calvarial osteolysis and on the inflammation response in BMDMs were reversed by ERalpha antagonist and by ERalpha-siRNA interference.	icariin	26-33	estrogen receptor 1 (alpha)	Mus musculus	147-154	
34803690-14	2021	The protective effects of icariin on CoCrMo particle-induced mouse calvarial osteolysis and on the inflammation response in BMDMs were reversed by ERalpha antagonist and by ERalpha-siRNA interference.	icariin	26-33	estrogen receptor 1 (alpha)	Mus musculus	173-180	
34803690-15	2021	In conclusion, icariin attenuates wear particle-induced inflammation and osteolysis via down-regulation of the ERalpha-mediated NF-kappaB signaling pathway in macrophages.	icariin	15-22	estrogen receptor 1 (alpha)	Mus musculus	111-118	
33339654-12	2021	The activation of ERalpha and Akt phosphorylation by icariin in MC3T3-E1 cells and the osteogenic effects of icariin on ALP activity in mature osteoblasts were shown to be IGF-IR-dependent.	icariin	53-60	estrogen receptor 1 (alpha)	Mus musculus	18-25	
33339654-13	2021	CONCLUSION: Our findings reveal that icariin activates both ERalpha and Akt via enhancing rapid induction of IGF-1 signaling in osteoblastic cells for osteogenesis and might be regarded as a novel pathway-selective phytoestrogen for management of postmenopausal osteoporosis.	icariin	37-44	estrogen receptor 1 (alpha)	Mus musculus	60-67	
23764463-0	2013	Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation.	icariin	0-7	estrogen receptor 1 (alpha)	Mus musculus	85-102	
23764463-8	2013	Interestingly, treatment of osteoblasts with estrogen receptor antagonist ICI182780 attenuated Icariin-mediated effect of proliferation and mineralization, associated with suppression of ERK and JNK phosphorylation.	icariin	95-102	estrogen receptor 1 (alpha)	Mus musculus	45-62	
27186315-11	2016	While the CORT levels were decreased by ICA at mid or high doses, the expressions of GR, ERalpha and ERbeta were up-regulated by estrogen or different doses of ICA in a dosedependent manner.	icariin	160-163	estrogen receptor 1 (alpha)	Mus musculus	89-96