PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31251943-0	2019	Icariin protects rotenone-induced neurotoxicity through induction of SIRT3.	icariin	0-7	sirtuin 3	Rattus norvegicus	69-74	
31251943-7	2019	The cytoprotective effect of ICA was abolished in ROT-treated cells by SIRT3 inhibitor 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP), along with a resultant decrease in PGC-1alpha expression.	icariin	29-32	sirtuin 3	Rattus norvegicus	71-76	
31251943-8	2019	In addition, knockdown of PGC-1alpha by siRNA suppressed ICA-mediated protective effects but did not affect SIRT3 expression, indicating the role of regulation of PGC-1alpha by SIRT3 in the protective action of ICA.	icariin	57-60	sirtuin 3	Rattus norvegicus	177-182	
31251943-8	2019	In addition, knockdown of PGC-1alpha by siRNA suppressed ICA-mediated protective effects but did not affect SIRT3 expression, indicating the role of regulation of PGC-1alpha by SIRT3 in the protective action of ICA.	icariin	211-214	sirtuin 3	Rattus norvegicus	177-182	
31251943-10	2019	However, these protective effects of ICA on ROT-treated cells was markedly abolished by SIRT3 inhibitor 3-TYP.	icariin	37-40	sirtuin 3	Rattus norvegicus	88-93	
31251943-11	2019	Our findings demonstrate that ICA exerts a neuroprotective role through upregulation of SIRT3.	icariin	30-33	sirtuin 3	Rattus norvegicus	88-93	
31251943-3	2019	This study aimed to determine whether ICA exerts neuroprotective effects on rotenone (ROT)-induced neurotoxicity through activation of SIRT3.	icariin	38-41	sirtuin 3	Rattus norvegicus	135-140	
31251943-5	2019	Administration of ICA significantly alleviated the loss of DA neurons, improved behavioral function, and concomitantly enhanced SIRT3 and PGC-1alpha expressions.	icariin	18-21	sirtuin 3	Rattus norvegicus	128-133