PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29891857-10	2018	In addition, ICA treatment recovered the decreased bone-related gene expression, including alkaline phosphatase (ALP), bone glaprotein (BGP), and osteoprotegerin/receptor activator of the NF-kappaB ligand ratio (OPG/RANKL), in the tibia and the decreased bone resorption marker TRACP-5b levels in serum caused by simulated microgravity.	icariin	13-16	TNF receptor superfamily member 11b	Homo sapiens	212-215	
30066868-5	2018	Furthermore, the levels of bone morphogenetic protein 2, collagen I, osteoprotegerin and alkaline phosphatase were markedly elevated by icariin, indicating that icariin was able to promote the osteogenic differentiation capability of HPDLCs.	icariin	161-168	TNF receptor superfamily member 11b	Homo sapiens	69-84	
25270538-0	2014	Effects of icariin on the regulation of the OPG-RANKL-RANK system are mediated through the MAPK pathways in IL-1beta-stimulated human SW1353 chondrosarcoma cells.	icariin	11-18	TNF receptor superfamily member 11b	Homo sapiens	44-47	
32760277-4	2020	Furthermore, Western blot and RT-qPCR analyses showed that treatment with ICA (20-30 microg/ml) had similar increase effect with BMP-2 (50 microg/ml) on the protein and mRNA levels of BMP-2, osteoprotegerin (OPG), and alkaline phosphatase (ALP) mRNAs.	icariin	74-77	TNF receptor superfamily member 11b	Homo sapiens	191-206	
32760277-4	2020	Furthermore, Western blot and RT-qPCR analyses showed that treatment with ICA (20-30 microg/ml) had similar increase effect with BMP-2 (50 microg/ml) on the protein and mRNA levels of BMP-2, osteoprotegerin (OPG), and alkaline phosphatase (ALP) mRNAs.	icariin	74-77	TNF receptor superfamily member 11b	Homo sapiens	208-211	
27061090-7	2016	Results also demonstrated that the ratio of osteoprotegerin (Opg)/receptor activator of nuclear factor kappa B ligand (Rankl) expression was up-regulated following treatment with icariin.	icariin	179-186	TNF receptor superfamily member 11b	Homo sapiens	44-59	
27061090-7	2016	Results also demonstrated that the ratio of osteoprotegerin (Opg)/receptor activator of nuclear factor kappa B ligand (Rankl) expression was up-regulated following treatment with icariin.	icariin	179-186	TNF receptor superfamily member 11b	Homo sapiens	61-64	
23714056-0	2013	[Effect of icariin on the expression of receptor activator nuclear factor-kappaB ligand and osteoprotegerin of human periodontal ligament cells].	icariin	11-18	TNF receptor superfamily member 11b	Homo sapiens	92-107	
23714056-1	2013	OBJECTIVE: To investigate the effect of icariin on the expression of receptor activator nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG) of human periodontal ligament cells (hPDLC) inhibited by sonicated extracts of Porphyromonas gingivalis (Pg).	icariin	40-47	TNF receptor superfamily member 11b	Homo sapiens	129-144	
23714056-1	2013	OBJECTIVE: To investigate the effect of icariin on the expression of receptor activator nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG) of human periodontal ligament cells (hPDLC) inhibited by sonicated extracts of Porphyromonas gingivalis (Pg).	icariin	40-47	TNF receptor superfamily member 11b	Homo sapiens	146-149	
23714056-5	2013	Compared with control group, RANKL and OPG expression changed in groups stimulated with 0.001, 0.01, 0.1, 1 mg/L icariin.	icariin	113-120	TNF receptor superfamily member 11b	Homo sapiens	39-42	
23714056-7	2013	CONCLUSIONS: The concentration of 0.1 mg/L icariin can inhibit hPDLC expression of RANKL in sonicated extracts of Pg and promote OPG expression.	icariin	43-50	TNF receptor superfamily member 11b	Homo sapiens	129-132