PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32427716-6	2020	Furthermore, ICA siginificantly increase the Bcl-2/Bax ratio by increasing the expression of anti-apoptotic protein Bcl-2, and decreasing the expression of pro-apoptotic protein Bax, and thus inhibit neurons apoptosis.	icariin	13-16	BCL2-associated X protein	Mus musculus	51-54	
32926492-4	2020	Moreover, icariin induced cell apoptosis via a mitochondria-mediated pathway, as indicated by upregulated ratio of Bax/Bcl-2 and ROS induction.	icariin	10-17	BCL2-associated X protein	Mus musculus	115-118	
32427716-6	2020	Furthermore, ICA siginificantly increase the Bcl-2/Bax ratio by increasing the expression of anti-apoptotic protein Bcl-2, and decreasing the expression of pro-apoptotic protein Bax, and thus inhibit neurons apoptosis.	icariin	13-16	BCL2-associated X protein	Mus musculus	178-181	
30447495-15	2019	In contrast, Bax expression was significantly higher in the aging group compared with all other groups (P < 0.01), and the Bcl-2/Bax ratio was markedly reduced in aging group compared with control, Ica 100 and 200 groups (P < 0.01), and Ica 50 group (P < 0.05).	icariin	201-204	BCL2-associated X protein	Mus musculus	13-16	
30447495-15	2019	In contrast, Bax expression was significantly higher in the aging group compared with all other groups (P < 0.01), and the Bcl-2/Bax ratio was markedly reduced in aging group compared with control, Ica 100 and 200 groups (P < 0.01), and Ica 50 group (P < 0.05).	icariin	201-204	BCL2-associated X protein	Mus musculus	132-135	
30447495-17	2019	Ovarian Bcl-2 protein levels and the Bcl-2/Bax ratio were significantly higher in the Ica 100 group than those in the Ica 50, 200 and aging groups (P < 0.05), and were similar or reduced (P < 0.05), respectively, compared to those in control group.	icariin	86-89	BCL2-associated X protein	Mus musculus	43-46	
30447495-19	2019	These findings suggest that Ica can improve ovarian follicular development, inhibit follicular atresia, decrease FSH and LH levels and increase E2, upregulate ovarian AMH expression and increase the Bcl-2/Bax ratio in aging mice.	icariin	28-31	BCL2-associated X protein	Mus musculus	205-208	
30745820-11	2019	Furthermore, ICA significantly inhibited the expression of ER stress apoptotic proteins caspase-12, CHOP, Bax/Bcl-2, caspase-9 and caspase-3.	icariin	13-16	BCL2-associated X protein	Mus musculus	106-109	
21687940-4	2011	Icariin caused a dose-dependent decrease in the viability of MLTC-1 cells, which coincided with an increase in cell apoptosis through regulation of the expression of Bcl-2/Bax and cytochrome c, activation of caspase-9 and -3.	icariin	0-7	BCL2-associated X protein	Mus musculus	172-175	
28190476-10	2017	The MPTP-induced changes of Bcl-2, Bax and caspase 3 protein expressions in the striatum could be reversed by icariin pretreatment.	icariin	110-117	BCL2-associated X protein	Mus musculus	35-38	
22013806-10	2011	CONCLUSION: In bronchial asthmatic mice, icariin could enhance the apoptosis of eosinophils and lessen their infiltration by decreasing the expression of Bcl-2 protein and increasing the expression of Bax protein in lung.	icariin	41-48	BCL2-associated X protein	Mus musculus	201-204	
22013806-0	2011	[Effects of icariin on Bcl-2 and Bax protein expressions and eosinophils apoptosis in bronchial asthmatic mice].	icariin	12-19	BCL2-associated X protein	Mus musculus	33-36	
22013806-1	2011	OBJECTIVE: To study the effects of icariin on Bcl-2 and Bax protein expressions and eosinophils apoptosis in bronchial asthmatic mice.	icariin	35-42	BCL2-associated X protein	Mus musculus	56-59