PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24550686-8	2014	The intragastric administration of icariin to Tg mice for 6 months (from 4 to 10 months of age) improved the learning-memory abilities and significantly decreased the Abeta contents, amyloid plaques, and APP and BACE-1 levels in the hippocampus.	icariin	35-42	beta-site APP cleaving enzyme 1	Mus musculus	212-218	
26584824-4	2016	RESULTS: Icariin significantly improved spatial learning and memory retention in 3 x Tg-AD mice, promoted neuronal cell activity as identified by the enhancement of brain metabolite N-acetylaspartate level and ATP production in AD mice, preserved the expressions of mitochondrial key enzymes COX IV, PDHE1alpha, and synaptic protein PSD95, reduced Abeta plaque deposition in the cortex and hippocampus of AD mice, and inhibited beta-site APP cleavage enzyme 1 (BACE1) expression.	icariin	9-16	beta-site APP cleaving enzyme 1	Mus musculus	461-466