PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33553429-0 2021 Icariin Promotes the Osteogenesis of Bone Marrow Mesenchymal Stem Cells through Regulating Sclerostin and Activating the Wnt/beta-Catenin Signaling Pathway. icariin 0-7 catenin beta 1 Rattus norvegicus 125-137 33553429-6 2021 Based on our previous research, we hypothesized that ICA promotes bone formation via the sclerostin/Wnt/beta-catenin signaling pathway. icariin 53-56 catenin beta 1 Rattus norvegicus 104-116 33553429-10 2021 Mechanistically, ICA exerted these effects by activating the Wnt/beta-catenin pathway. icariin 17-20 catenin beta 1 Rattus norvegicus 65-77 32525771-0 2020 Icariin accelerate fracture healing via activation of WNT1/beta-catenin osteogenic signaling pathway. icariin 0-7 catenin beta 1 Rattus norvegicus 59-71 27764755-0 2016 Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ERalpha-Wnt/beta-catenin signaling pathway. icariin 0-7 catenin beta 1 Rattus norvegicus 107-119 28486190-4 2017 Icariin (0.1muM) upregulated TAZ, Runx2, beta-catenin, Osteopotin, and Dlx5 expression mainly at the early stage of osteogenic differentiation, and increased osteocalcin expression at the late stage. icariin 0-7 catenin beta 1 Rattus norvegicus 41-53 28486190-6 2017 Moreover, ICI 182780 (the estrogen receptor alpha inhibitor) or DKK1 (the Wnt/beta-catenin pathway inhibitor), inhibited the icariin-induced increase in TAZ expression. icariin 125-132 catenin beta 1 Rattus norvegicus 78-90 28486190-8 2017 Taken together, our results demonstrate that icariin promotes the osteogenic differentiation of rBMSCs by increasing TAZ expression, and that the increased TAZ expression induced by icariin is mostly mediated by the ERalpha and Wnt/beta-catenin pathway. icariin 182-189 catenin beta 1 Rattus norvegicus 232-244 30066892-0 2018 Icariin promotes the proliferation and differentiation of osteoblasts from the rat mandible by the Wnt/beta-catenin signalling pathway. icariin 0-7 catenin beta 1 Rattus norvegicus 103-115 30066892-7 2018 Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible. icariin 13-16 catenin beta 1 Rattus norvegicus 56-68 30066892-7 2018 Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible. icariin 13-16 catenin beta 1 Rattus norvegicus 209-221 30066892-7 2018 Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible. icariin 13-16 catenin beta 1 Rattus norvegicus 209-221 30066892-7 2018 Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible. icariin 323-326 catenin beta 1 Rattus norvegicus 209-221 30066892-7 2018 Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible. icariin 323-326 catenin beta 1 Rattus norvegicus 209-221 30066892-8 2018 In conclusion, these results support the osteogenic effects of ICA (0.15 to 15 microM) on osteoblastic cells from the rat mandible and the participation of the Wnt/beta-catenin signalling pathway. icariin 63-66 catenin beta 1 Rattus norvegicus 164-176 27764755-3 2016 Here, we investigated whether icariin could promote osteogenesis of rBMSCs through modulating the estrogen receptor alpha (ERalpha) and Wnt/beta-catenin signaling pathways, which implicated in rBMSCs osteogenesis. icariin 30-37 catenin beta 1 Rattus norvegicus 140-152 27764755-6 2016 Additionally, icariin (0.1muM) significantly up-regulated the expression of osteogenic genes (Runx2, osteopotin, DLX5, osteocalcin, collagen type I, and ERalpha) and Wnt signal members (beta-catenin, Lef1, TCF7, c-jun, c-myc, and cyclin D). icariin 14-21 catenin beta 1 Rattus norvegicus 186-198 27764755-7 2016 Furthermore, icariin stimulated the activation of beta-catenin as evidenced by increased total beta-catenin protein and nuclear translocation. icariin 13-20 catenin beta 1 Rattus norvegicus 50-62 27764755-7 2016 Furthermore, icariin stimulated the activation of beta-catenin as evidenced by increased total beta-catenin protein and nuclear translocation. icariin 13-20 catenin beta 1 Rattus norvegicus 95-107 27468552-10 2016 Compared with the control group, total and nuclear beta-catenin proteins, as well as beta-catenin mRNA expression, were all increased with icariin treatment. icariin 139-146 catenin beta 1 Rattus norvegicus 51-63 27468552-10 2016 Compared with the control group, total and nuclear beta-catenin proteins, as well as beta-catenin mRNA expression, were all increased with icariin treatment. icariin 139-146 catenin beta 1 Rattus norvegicus 85-97