PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17883938-0	2007	Icariin promotes expression of PGC-1alpha, PPARalpha, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro.	icariin	0-7	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	31-41	
20381504-10	2010	In result, neurological scores, infarct size and brain edema were all significantly improved, the cortical expressions of SIRT1 and PGC-1alpha were higher with ICA compared to the control (P < 0.05), and reversed by SIRT1 inhibitor III/PGC-1alpha siRNA.	icariin	160-163	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	132-142	
20381504-10	2010	In result, neurological scores, infarct size and brain edema were all significantly improved, the cortical expressions of SIRT1 and PGC-1alpha were higher with ICA compared to the control (P < 0.05), and reversed by SIRT1 inhibitor III/PGC-1alpha siRNA.	icariin	160-163	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	239-249	
20381504-11	2010	In conclusion, ICA protects against brain ischemic injury by increasing the SIRT1 and PGC-1alpha expression, potentially to be a neuroprotectant for ischemic brain injury.	icariin	15-18	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	86-96	
34906049-0	2021	AMPK/PGC-1alpha/GLUT4-Mediated Effect of Icariin on Hyperlipidemia-Induced Non-Alcoholic Fatty Liver Disease and Lipid Metabolism Disorder in Mice.	icariin	41-48	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	5-15	
34906049-11	2021	Additionally, icariin mitigated the NAFLD-induced up-regulation of the cleaved caspase 3/9, SREBP-1c, and DGAT-2 levels, and enhanced the expression level of CPT-1, p-ACC/ACC, AMPKalpha1, PGC-1alpha, and GLUT4.	icariin	14-21	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	188-198	
31055234-11	2019	In vivo, icariin decreased body weight gain in C57BL/6 mice and increased FNDC5, PGC-1alpha, and p-AMPK expression levels in skeletal muscle.	icariin	9-16	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	81-91	
17883938-9	2007	CONCLUSION: Taken together, icariin promoted the expression of PGC-1alpha, PPARalpha, and NRF-1 during cardiomyocyte differentiation of murine ES cells in vitro and the effect was partly responsible for the activation of the p38 MAPK.	icariin	28-35	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	63-73	
17883938-1	2007	AIM: To investigate the effect of icariin on the expression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha), peroxisome proliferator-activated receptor alpha (PPARalpha), and nuclear respiratory factor 1 (NRF-1) on cardiomyocyte differentiation of murine embryonic stem (ES) cells in vitro.	icariin	34-41	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	63-131	
17883938-1	2007	AIM: To investigate the effect of icariin on the expression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha), peroxisome proliferator-activated receptor alpha (PPARalpha), and nuclear respiratory factor 1 (NRF-1) on cardiomyocyte differentiation of murine embryonic stem (ES) cells in vitro.	icariin	34-41	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	133-143	
17883938-6	2007	RESULTS: The application of icariin significantly induced the cardiomyocyte differentiation of EB as indicated by the promoted expression of alpha-actinin and troponin T. The expression of PGC-1alpha, PPARalpha, and NRF-1 increased coincidently in early differentiation and the increase was dose-dependently upregulated by icariin treatment.	icariin	28-35	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	189-199