PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30378304-10 2018 Western blot results indicated that icariin significantly increased the protein expression level of caspase-3 in SKOV3 and SKVCR cells (P<0.05). icariin 36-43 caspase 3 Homo sapiens 100-109 30008817-12 2018 Semi-quantitative PCR and western blot analysis revealed that the expression levels of p-GSK3beta, beta-catenin, c-Myc and cyclin D1 in cells after ICA treatment were significantly downregulated (p<0.01), while the expression level of caspase-3 was significantly increased (p<0.01). icariin 148-151 caspase 3 Homo sapiens 238-247 29532884-0 2018 Protective effects of icariin on human vascular endothelial cells induced by oxidized low-density lipoprotein via modulating caspase-3 and Bcl-2. icariin 22-29 caspase 3 Homo sapiens 125-134 29532884-6 2018 The findings of the present study indicated that icariin prevented injury and apoptosis in HUVECs following ox-LDL treatment, in particular via the regulation of protein and mRNA expression levels of Bcl-2 and caspase-3. icariin 49-56 caspase 3 Homo sapiens 210-219 23274410-13 2013 In GBC-SD cells, icariin significantly inhibited both the constitutive and gemcitabine-induced NF-kappaB activity, enhanced caspase-3 activity, induced G(0)-G(1) phase arrest, and suppressed the expression of Bcl-2, Bcl-xL and surviving proteins. icariin 17-24 caspase 3 Homo sapiens 124-133 27545131-14 2016 (8) The expression of CYC and caspase-3 was significantly reduced in the mitochondria and increased in cytoplasm post GSNO treatment compared to blank control group, which could be reversed by pretreatment with high, medium and low concentration ICA(all P<0.05). icariin 246-249 caspase 3 Homo sapiens 30-39 26049256-3 2015 Additionally, ICA exhibited potent anticancer activity, as evidenced by reductions in A549 cell adhesion, migration and intracellular glutathione (GSH) levels and increases in the apoptotic index, Caspase 3 activity, and reactive oxygen species. icariin 14-17 caspase 3 Homo sapiens 197-206 25845681-9 2015 Icariin concomitantly suppressed cell proliferation, accelerated apoptosis and increased caspase-3 activity in the A2780 cells. icariin 0-7 caspase 3 Homo sapiens 89-98 33891785-10 2021 In addition, ICA significantly increased the expression of P47phox and iNOS, decreased p-JNK/JNK, p-P38/P38, Bax/Bcl-2, active caspase-3, and active caspase-9. icariin 13-16 caspase 3 Homo sapiens 127-136 15967384-7 2005 Furthermore, pretreatment with icariin decreased the expression of caspase-3, which was known to be involved as a key role executor in H2O2-induced cell apoptosis. icariin 31-38 caspase 3 Homo sapiens 67-76 35114909-7 2022 The assay results demonstrated that ICA can promote the apoptosis of SKOV3 cells as indicated by the proapoptotic markers Bax, Bcl-xl and Caspase-3 and the key factors of the NF-(Formula: see text)B signaling pathway (NF-(Formula: see text)Bp65, p-NF-(Formula: see text)Bp65, p-I(Formula: see text)B(Formula: see text) and I(Formula: see text)B(Formula: see text). icariin 36-39 caspase 3 Homo sapiens 138-147 34447463-18 2021 The content of cleaved caspase 3/7 in the icariin-protected group was significantly lower than that in the group without icariin (P<0.05). icariin 42-49 caspase 3 Homo sapiens 23-34 34306206-10 2021 In addition, treatment of OSCC cells with ICA upregulated the protein expression of cleaved-caspase-3 and increased the cleaved-caspase-3/caspase-3 ratio. icariin 42-45 caspase 3 Homo sapiens 138-147 31424652-13 2019 The anticancer effects of Icariin were due to induction of apoptosis which was accompanied with cleavage of caspase 3 and 9, upregulation of Bax and downregulation of Bcl-2. icariin 26-33 caspase 3 Homo sapiens 108-123 30551506-8 2019 ICA significantly suppressed cell viability in a dose-dependent manner and induced apoptosis by regulating Bcl-2, Bax and cleaced-Caspase-3/-9 expression in SW579 and TPC1 cells (p < 0.001). icariin 0-3 caspase 3 Homo sapiens 130-142