PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31785072-10	2019	Apart from this, the activation of PI3K/AKT and Raf1/ERK1/2 signaling pathways was inhibited by ICA through upregulating miR-7 expression.	icariin	96-99	mitogen-activated protein kinase 3	Homo sapiens	53-59	
31785072-11	2019	The study released that ICA inhibited both BPH-1 and RWPE-1 cells proliferation, migration and promoted apoptosis by upregulating the levels of miR-7 expression, which was related to PI3K/AKT and Raf1/ERK1/2 signaling pathways.	icariin	24-27	mitogen-activated protein kinase 3	Homo sapiens	201-207	
28925164-0	2016	[Effects of icariin on proliferation of vascular smooth muscle cell induced by ox-LDL via impacting MAPK signaling pathway].	icariin	12-19	mitogen-activated protein kinase 3	Homo sapiens	100-104	
30873034-9	2019	Further studies showed that icariin attenuated iron overload induced inactivation of the PI3K/AKT/mTOR pathway and activation of the ERK1/2 and JNK pathways.	icariin	28-35	mitogen-activated protein kinase 3	Homo sapiens	133-139	
28925164-1	2016	This paper was aimed to study the effects of icariin (ICA) on the proliferation of vascular smooth muscle cell (VSMC) induced by oxidized low density lipoprotein (ox-LDL), and the molecular mechanism of the expression of proliferating cell nuclear antigen (PCNA) and MAPK signaling pathway.	icariin	45-52	mitogen-activated protein kinase 3	Homo sapiens	267-271	
28925164-4	2016	These results indicate that ICA can inhibit the proliferation of VSMC by reducing the expression of PCNA and blocking the p38MAPK and ERK1/2 signaling pathway.	icariin	28-31	mitogen-activated protein kinase 3	Homo sapiens	134-140	
25270538-0	2014	Effects of icariin on the regulation of the OPG-RANKL-RANK system are mediated through the MAPK pathways in IL-1beta-stimulated human SW1353 chondrosarcoma cells.	icariin	11-18	mitogen-activated protein kinase 3	Homo sapiens	91-95	
25787271-7	2015	These antiapoptotic and antiautophagic effects of Icariin are possibly mediated by restoring the loss of mammalian target of rapamycin /p70S6K/4EBP1 phosphorylation as well as attenuation of ATF2 and ERK1/2 protein levels after H2 O2 treatment.	icariin	50-57	mitogen-activated protein kinase 3	Homo sapiens	200-206	
25270538-8	2014	The results from western blot analysis revealed that treatment with icariin decreased the levels of p-p38 and increased the levels of p-ERK1/2 in the IL-1beta-stimulated SW1353 cells.	icariin	68-75	mitogen-activated protein kinase 3	Homo sapiens	136-142	
24718680-0	2014	Icariin and icaritin stimulate the proliferation of SKBr3 cells through the GPER1-mediated modulation of the EGFR-MAPK signaling pathway.	icariin	0-7	mitogen-activated protein kinase 3	Homo sapiens	114-118	
24718680-7	2014	Our data also demonstrated that ICA and ICT increased the phosphorylation of ERK1/2.	icariin	32-35	mitogen-activated protein kinase 3	Homo sapiens	77-83	
24718680-8	2014	The ICA- and ICT-stimulated ERK1/2 phosphorylation was blocked by pre-treatment of the cells with G-15 and AG-1478 or PD 98059.	icariin	4-7	mitogen-activated protein kinase 3	Homo sapiens	28-34	
24718680-9	2014	Flow cytometric analysis confirmed that the ICA- and ICT-stimulated SKBr3 cell proliferation involved the GPER1-mediated modulation of the EGFR-MAPK signaling pathway.	icariin	44-47	mitogen-activated protein kinase 3	Homo sapiens	144-148	
20554188-9	2011	On osteoclasts, icariin suppresses LPS-mediated activation of the p38 and JNK; while on the osteoblasts, icariin reduced the LPS-induced activation of ERK1/2 and I-kappa-B-alpha (IkappaBalpha), but increased the activation of p38.	icariin	105-112	mitogen-activated protein kinase 3	Homo sapiens	151-157	
20416296-1	2010	Icariin, a flavonoid isolated from Epimedii herba, stimulated phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser1177, Akt (Ser473) and ERK1/2 (Thr202/Tyr204).	icariin	0-7	mitogen-activated protein kinase 3	Homo sapiens	151-157	
20416296-4	2010	The icariin-induced eNOS phosphorylation was inhibited by wortmannin, a phosphatidylinositol 3-kinase (PI3K) inhibitor and partially attenuated by PD98059, an upstream inhibitor for ERK1/2.	icariin	4-11	mitogen-activated protein kinase 3	Homo sapiens	182-188	
20416296-6	2010	PI3K/Akt and MAPK-ERK kinase (MEK)/ERK1/2 pathways were involved in the phosphorylation of eNOS by icariin.	icariin	99-106	mitogen-activated protein kinase 3	Homo sapiens	35-41	
34147477-6	2021	Under basal conditions of astrocytes, icariin and icaritin treatment alone increased the phosphorylation of ERK1/2 and AKT, which could be blocked by JB-1.	icariin	38-45	mitogen-activated protein kinase 3	Homo sapiens	108-114