PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34167449-0 2021 Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling. icariin 0-7 AKT serine/threonine kinase 1 Rattus norvegicus 92-95 34167449-7 2021 The apoptotic rate of OA chondrocytes was markedly elevated by 3-methyladenine and suppressed by rapamycin and icariin; autophagy genes were drastically downregulated in the 3-methyladenine group and upregulated in the rapamycin and icariin groups; and the PI3K/AKT/mTOR signaling pathway was activated by 3-methyladenine and inhibited by rapamycin and icariin. icariin 111-118 AKT serine/threonine kinase 1 Rattus norvegicus 262-265 34167449-7 2021 The apoptotic rate of OA chondrocytes was markedly elevated by 3-methyladenine and suppressed by rapamycin and icariin; autophagy genes were drastically downregulated in the 3-methyladenine group and upregulated in the rapamycin and icariin groups; and the PI3K/AKT/mTOR signaling pathway was activated by 3-methyladenine and inhibited by rapamycin and icariin. icariin 233-240 AKT serine/threonine kinase 1 Rattus norvegicus 262-265 34167449-7 2021 The apoptotic rate of OA chondrocytes was markedly elevated by 3-methyladenine and suppressed by rapamycin and icariin; autophagy genes were drastically downregulated in the 3-methyladenine group and upregulated in the rapamycin and icariin groups; and the PI3K/AKT/mTOR signaling pathway was activated by 3-methyladenine and inhibited by rapamycin and icariin. icariin 353-360 AKT serine/threonine kinase 1 Rattus norvegicus 262-265 34167449-9 2021 Taken together, these findings indicate that icariin alleviates OA by regulating the autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling. icariin 45-52 AKT serine/threonine kinase 1 Rattus norvegicus 129-132 32727295-11 2020 BDNF knockdown not only suppressed the expressions of BDNF and TrkB in Abeta cell models but also effectively prevented the phosphorylation of ERK/Akt; however, these phenomena were significantly alleviated by ICA treatment. icariin 210-213 AKT serine/threonine kinase 1 Rattus norvegicus 147-150 33339654-10 2021 RNA-sequencing analysis of mRNA from BMSCs revealed that icariin at 500 ppm significantly altered IGF-1 signaling as well as PI3K-Akt pathways. icariin 57-64 AKT serine/threonine kinase 1 Rattus norvegicus 130-133 32727295-12 2020 DISCUSSION: ICA promoted the proliferation and differentiation of Abeta25-35-treated hippocampal neural stem cells through BDNF-TrkB-ERK/Akt signaling pathway. icariin 12-15 AKT serine/threonine kinase 1 Rattus norvegicus 137-140 31772646-0 2019 Icariin reduces high glucose-induced endothelial progenitor cell dysfunction via inhibiting the p38/CREB pathway and activating the Akt/eNOS/NO pathway. icariin 0-7 AKT serine/threonine kinase 1 Rattus norvegicus 132-135 32341897-0 2020 Icariin protects against sodium azide-induced neurotoxicity by activating the PI3K/Akt/GSK-3beta signaling pathway. icariin 0-7 AKT serine/threonine kinase 1 Rattus norvegicus 83-86 32341897-7 2020 The role of ICA in the PI3K/Akt/GSK-3beta signaling pathway was explored by Western blotting. icariin 12-15 AKT serine/threonine kinase 1 Rattus norvegicus 28-31 32341897-12 2020 Conclusions: These results suggest that ICA protects against NaN3-induced neurotoxicity in PC12 cells by activating the PI3K/Akt/GSK-3beta signaling pathway. icariin 40-43 AKT serine/threonine kinase 1 Rattus norvegicus 125-128 31612304-7 2019 We also observed that ICA enhanced the phosphorylation of protein kinase B (PKB/AKT) and p70 ribosomal protein S6 kinase (p70S6K). icariin 22-25 AKT serine/threonine kinase 1 Rattus norvegicus 76-83 31772646-9 2019 Increased Akt and endothelial nitric oxide (NO) synthase (eNOS) activation was also observed after icariin treatment (FC: 0.64+-0.08, P=0.0047 vs. HG group for Akt; FC:0.53+-0.05, P=0.0019 vs. HG group for eNOS), which was followed by increased NO production (FC: 0.69+-0.06, P=0.0064 vs. HG group). icariin 99-106 AKT serine/threonine kinase 1 Rattus norvegicus 10-13 31772646-9 2019 Increased Akt and endothelial nitric oxide (NO) synthase (eNOS) activation was also observed after icariin treatment (FC: 0.64+-0.08, P=0.0047 vs. HG group for Akt; FC:0.53+-0.05, P=0.0019 vs. HG group for eNOS), which was followed by increased NO production (FC: 0.69+-0.06, P=0.0064 vs. HG group). icariin 99-106 AKT serine/threonine kinase 1 Rattus norvegicus 160-163 31772646-10 2019 In conclusion, icariin attenuated HG-induced EPC dysfunction, which may be partially attributed to the inhibition of the p38/CREB pathway and the activation of the Akt/eNOS/NO pathway. icariin 15-22 AKT serine/threonine kinase 1 Rattus norvegicus 164-167 31507078-6 2019 ICA significantly promoted BMECs migration, tube formation, the angiogenesis-related cytokines expression and the activation of Akt. icariin 0-3 AKT serine/threonine kinase 1 Rattus norvegicus 128-131 31618892-3 2019 However, there are few studies that have focused on the involvement of the phosphatidylinositol 3-kinase (PI3K)/serine-threonine protein kinase (AKT) signaling in mediating the perimenopausal depression effects of icariin. icariin 214-221 AKT serine/threonine kinase 1 Rattus norvegicus 145-148 31618892-5 2019 The aim of the present study was to explore the effect of icariin on the expression of the PI3K-AKT pathway related to proteins in a rat model of perimenopausal depression. icariin 58-65 AKT serine/threonine kinase 1 Rattus norvegicus 96-99 31597358-13 2019 Conclusively, the combination of Icariin and exercise significantly prevent OVX-induced bone loss and increase osteoblast differentiation and the ability of mineralization compared with exercise alone; the changes might be regulated partly by ER/Akt/-catenin pathway. icariin 33-40 AKT serine/threonine kinase 1 Rattus norvegicus 246-249 28536643-0 2017 Icariin Prevents H2O2-Induced Apoptosis via the PI3K/Akt Pathway in Rat Nucleus Pulposus Intervertebral Disc Cells. icariin 0-7 AKT serine/threonine kinase 1 Rattus norvegicus 53-56 32186080-6 2018 Compared with the high glucose group, the apoptosis rate of hippocampal neurons decreased significantly (P < 0.01), and p-Akt/Akt and Bcl-2/Bax increased significantly (P < 0.05)in icariin group and Akt agonist group. icariin 181-188 AKT serine/threonine kinase 1 Rattus norvegicus 122-125 32186080-6 2018 Compared with the high glucose group, the apoptosis rate of hippocampal neurons decreased significantly (P < 0.01), and p-Akt/Akt and Bcl-2/Bax increased significantly (P < 0.05)in icariin group and Akt agonist group. icariin 181-188 AKT serine/threonine kinase 1 Rattus norvegicus 126-129 32186080-7 2018 Compared with the icariin + Akt inhibitor group, the apoptosis rate of hippocampal neurons decreased significantly (P < 0.01), and p-Akt/Akt and Bcl-2/Bax increased significantly (P < 0.01) in icariin group. icariin 18-25 AKT serine/threonine kinase 1 Rattus norvegicus 133-136 32186080-8 2018 CONCLUSION: Icariin could reduce the apoptosis of neurons cultured in high glucose, which may be achieved by increasing the phosphorylation of Akt protein in Akt signal pathway, then increasing the expression of Bcl-2 and inhibiting the expression of Bax. icariin 12-19 AKT serine/threonine kinase 1 Rattus norvegicus 143-146 32186080-8 2018 CONCLUSION: Icariin could reduce the apoptosis of neurons cultured in high glucose, which may be achieved by increasing the phosphorylation of Akt protein in Akt signal pathway, then increasing the expression of Bcl-2 and inhibiting the expression of Bax. icariin 12-19 AKT serine/threonine kinase 1 Rattus norvegicus 158-161 28350842-15 2017 Our results suggested that icariin was an effective adjuvant for enhancing ADSC-based therapy of DMEM, which may be ascribed to their protection of ADSCs against oxidative stress via the regulation of PI3K/Akt-STAT3 signal pathway. icariin 27-34 AKT serine/threonine kinase 1 Rattus norvegicus 206-209 28536643-7 2017 Icariin pretreatment significantly decreased H2O2-induced apoptosis and intracellular ROS and upregulated p-Akt and BCL-2 and downregulated caspase-3 and Bax. icariin 0-7 AKT serine/threonine kinase 1 Rattus norvegicus 108-111 32262676-8 2015 Furthermore, the activation of the AKT signaling pathway was observed in BMSCs upon treatment with icariin, and these enhancement effects could be blocked by LY294002, which suggested that the AKT signaling pathway was involved in the osteogenic differentiation and angiogenic factor expression of BMSCs induced by icariin. icariin 99-106 AKT serine/threonine kinase 1 Rattus norvegicus 35-38 25724443-4 2015 Moreover, our results showed that icariin postconditioning exerts cardioprotective effect against myocardial I/R injury through activating PI3K/Akt using PI3K/Akt inhibitor LY294002. icariin 34-41 AKT serine/threonine kinase 1 Rattus norvegicus 144-147 25724443-4 2015 Moreover, our results showed that icariin postconditioning exerts cardioprotective effect against myocardial I/R injury through activating PI3K/Akt using PI3K/Akt inhibitor LY294002. icariin 34-41 AKT serine/threonine kinase 1 Rattus norvegicus 159-162 25663532-10 2015 These results suggest that icariin protects against myocardial ischemia reperfusion injury in rats by activating the PI3K/Akt/eNOS-dependent signal pathways and may be a useful drug for angiogenic therapy. icariin 27-34 AKT serine/threonine kinase 1 Rattus norvegicus 122-125 32262676-8 2015 Furthermore, the activation of the AKT signaling pathway was observed in BMSCs upon treatment with icariin, and these enhancement effects could be blocked by LY294002, which suggested that the AKT signaling pathway was involved in the osteogenic differentiation and angiogenic factor expression of BMSCs induced by icariin. icariin 99-106 AKT serine/threonine kinase 1 Rattus norvegicus 193-196 32262676-8 2015 Furthermore, the activation of the AKT signaling pathway was observed in BMSCs upon treatment with icariin, and these enhancement effects could be blocked by LY294002, which suggested that the AKT signaling pathway was involved in the osteogenic differentiation and angiogenic factor expression of BMSCs induced by icariin. icariin 315-322 AKT serine/threonine kinase 1 Rattus norvegicus 35-38 32262676-8 2015 Furthermore, the activation of the AKT signaling pathway was observed in BMSCs upon treatment with icariin, and these enhancement effects could be blocked by LY294002, which suggested that the AKT signaling pathway was involved in the osteogenic differentiation and angiogenic factor expression of BMSCs induced by icariin. icariin 315-322 AKT serine/threonine kinase 1 Rattus norvegicus 193-196 32262676-11 2015 These results demonstrated that icariin could enhance osteogenic differentiation and angiogenic factor expression of BMSCs via the AKT signaling pathway, moreover, the novel micro/nano HAp granules could act as carriers for icariin to repair bone defects via enhancing osteogenesis and angiogenesis. icariin 32-39 AKT serine/threonine kinase 1 Rattus norvegicus 131-134 25705234-0 2015 Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3K/Akt Pathway in PC-12 Cells. icariin 0-7 AKT serine/threonine kinase 1 Rattus norvegicus 61-64 25705234-4 2015 Results of western blot analysis revealed that the selective phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 suppressed icariin-induced Akt phosphorylation, suggesting that the protective effects of icariin are associated with activation of the PI3K/Akt signaling pathway. icariin 128-135 AKT serine/threonine kinase 1 Rattus norvegicus 144-147 25705234-4 2015 Results of western blot analysis revealed that the selective phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 suppressed icariin-induced Akt phosphorylation, suggesting that the protective effects of icariin are associated with activation of the PI3K/Akt signaling pathway. icariin 128-135 AKT serine/threonine kinase 1 Rattus norvegicus 258-261 24956021-5 2014 It was found that icariin dose-dependently increased ALP activity, and treatment at the optimal concentration (10(-5)M) increased NOS activity, iNOS and eNOS expression, NO production, sGC and cGMP contents and PKG expression besides the phosphorylation of AKT. icariin 18-25 AKT serine/threonine kinase 1 Rattus norvegicus 257-260 24956021-0 2014 Icariin stimulates the osteogenic differentiation of rat bone marrow stromal cells via activating the PI3K-AKT-eNOS-NO-cGMP-PKG. icariin 0-7 AKT serine/threonine kinase 1 Rattus norvegicus 107-110 24956021-9 2014 These results suggest that the osteogenic effect of icariin involves the PI3K-AKT-eNOS-NO-cGMP-PKG signal pathway. icariin 52-59 AKT serine/threonine kinase 1 Rattus norvegicus 78-81 20708632-7 2010 Mechanism study showed that icariin could activate PI3K/Akt signaling pathway, resulting in an inhibitory effect on glycogen synthase kinase (GSK)-3beta, which is an important kinase response for tau protein hyperphosphorylation in the development of AD. icariin 28-35 AKT serine/threonine kinase 1 Rattus norvegicus 56-59 23336586-0 2013 Icariin delays homocysteine-induced endothelial cellular senescence involving activation of the PI3K/AKT-eNOS signaling pathway. icariin 0-7 AKT serine/threonine kinase 1 Rattus norvegicus 101-104 23336586-13 2013 We found that NO production and phosphorylation of AKT, ERK, and endothelial NO synthase (eNOS) were elevated by ICA in HUVECs. icariin 113-116 AKT serine/threonine kinase 1 Rattus norvegicus 51-54 23336586-17 2013 Activation of PI3K/Akt-eNOS-dependent signaling pathway may be responsible for this efficacy of ICA. icariin 96-99 AKT serine/threonine kinase 1 Rattus norvegicus 19-22