PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32427716-6	2020	Furthermore, ICA siginificantly increase the Bcl-2/Bax ratio by increasing the expression of anti-apoptotic protein Bcl-2, and decreasing the expression of pro-apoptotic protein Bax, and thus inhibit neurons apoptosis.	icariin	13-16	B cell leukemia/lymphoma 2	Mus musculus	45-50	
32926492-4	2020	Moreover, icariin induced cell apoptosis via a mitochondria-mediated pathway, as indicated by upregulated ratio of Bax/Bcl-2 and ROS induction.	icariin	10-17	B cell leukemia/lymphoma 2	Mus musculus	119-124	
32427716-6	2020	Furthermore, ICA siginificantly increase the Bcl-2/Bax ratio by increasing the expression of anti-apoptotic protein Bcl-2, and decreasing the expression of pro-apoptotic protein Bax, and thus inhibit neurons apoptosis.	icariin	13-16	B cell leukemia/lymphoma 2	Mus musculus	116-121	
22013806-0	2011	[Effects of icariin on Bcl-2 and Bax protein expressions and eosinophils apoptosis in bronchial asthmatic mice].	icariin	12-19	B cell leukemia/lymphoma 2	Mus musculus	23-28	
30447495-14	2019	The ovarian expression of AMH and Bcl-2 mRNA was significantly reduced in the aging group compared with those in control and Ica-treated groups (P < 0.01).	icariin	125-128	B cell leukemia/lymphoma 2	Mus musculus	34-39	
30447495-15	2019	In contrast, Bax expression was significantly higher in the aging group compared with all other groups (P < 0.01), and the Bcl-2/Bax ratio was markedly reduced in aging group compared with control, Ica 100 and 200 groups (P < 0.01), and Ica 50 group (P < 0.05).	icariin	201-204	B cell leukemia/lymphoma 2	Mus musculus	126-131	
30447495-17	2019	Ovarian Bcl-2 protein levels and the Bcl-2/Bax ratio were significantly higher in the Ica 100 group than those in the Ica 50, 200 and aging groups (P < 0.05), and were similar or reduced (P < 0.05), respectively, compared to those in control group.	icariin	86-89	B cell leukemia/lymphoma 2	Mus musculus	8-13	
30447495-19	2019	These findings suggest that Ica can improve ovarian follicular development, inhibit follicular atresia, decrease FSH and LH levels and increase E2, upregulate ovarian AMH expression and increase the Bcl-2/Bax ratio in aging mice.	icariin	28-31	B cell leukemia/lymphoma 2	Mus musculus	199-204	
28190476-10	2017	The MPTP-induced changes of Bcl-2, Bax and caspase 3 protein expressions in the striatum could be reversed by icariin pretreatment.	icariin	110-117	B cell leukemia/lymphoma 2	Mus musculus	28-33	
21687940-4	2011	Icariin caused a dose-dependent decrease in the viability of MLTC-1 cells, which coincided with an increase in cell apoptosis through regulation of the expression of Bcl-2/Bax and cytochrome c, activation of caspase-9 and -3.	icariin	0-7	B cell leukemia/lymphoma 2	Mus musculus	166-171	
30745820-11	2019	Furthermore, ICA significantly inhibited the expression of ER stress apoptotic proteins caspase-12, CHOP, Bax/Bcl-2, caspase-9 and caspase-3.	icariin	13-16	B cell leukemia/lymphoma 2	Mus musculus	110-115	
24948525-9	2014	Icariin treatment significantly improved miR-21 expression in all embryo stages, reduced the transcriptional levels of caspase 3 and PTEN, and increased the levels of Bcl-2.	icariin	0-7	B cell leukemia/lymphoma 2	Mus musculus	167-172	
22013806-1	2011	OBJECTIVE: To study the effects of icariin on Bcl-2 and Bax protein expressions and eosinophils apoptosis in bronchial asthmatic mice.	icariin	35-42	B cell leukemia/lymphoma 2	Mus musculus	46-51	
22013806-10	2011	CONCLUSION: In bronchial asthmatic mice, icariin could enhance the apoptosis of eosinophils and lessen their infiltration by decreasing the expression of Bcl-2 protein and increasing the expression of Bax protein in lung.	icariin	41-48	B cell leukemia/lymphoma 2	Mus musculus	154-159