PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35063771-0	2022	Icariin inhibits isoproterenol-induced cardiomyocyte hypertropic injury through activating autophagy via the AMPK/mTOR signaling pathway.	icariin	0-7	mechanistic target of rapamycin kinase	Homo sapiens	114-118	
35063771-6	2022	Mechanistically, ICA increased the phosphorylation levels of AMPK and autophagy-related markers beclin-1, Atg5 and the LC3II/I ratio, and decreased phosphorylated mTOR.	icariin	17-20	mechanistic target of rapamycin kinase	Homo sapiens	163-167	
31081049-0	2019	Icariin enhances the chemosensitivity of cisplatin-resistant ovarian cancer cells by suppressing autophagy via activation of the AKT/mTOR/ATG5 pathway.	icariin	0-7	mechanistic target of rapamycin kinase	Homo sapiens	133-137	
35114909-2	2022	Our previous research showed that TNF, MMP9, STAT3, PIK3CA, ERBB2, MTOR, IL2, PTGS2, KDR and F2 are important targets of ICA in the treatment of OC.	icariin	121-124	mechanistic target of rapamycin kinase	Homo sapiens	67-71	
31081049-9	2019	At the molecular level, rapamycin treatment or overexpression of ATG5 reversed the effects of icariin on the expression of autophagy-associated proteins, including microtubule-associated protein 1 light chain 3beta, Beclin-1, ATG5 and p62, and the AKT/mammalian target of rapamycin (mTOR) pathway.	icariin	94-101	mechanistic target of rapamycin kinase	Homo sapiens	252-281	
31081049-9	2019	At the molecular level, rapamycin treatment or overexpression of ATG5 reversed the effects of icariin on the expression of autophagy-associated proteins, including microtubule-associated protein 1 light chain 3beta, Beclin-1, ATG5 and p62, and the AKT/mammalian target of rapamycin (mTOR) pathway.	icariin	94-101	mechanistic target of rapamycin kinase	Homo sapiens	283-287	
30873034-9	2019	Further studies showed that icariin attenuated iron overload induced inactivation of the PI3K/AKT/mTOR pathway and activation of the ERK1/2 and JNK pathways.	icariin	28-35	mechanistic target of rapamycin kinase	Homo sapiens	98-102	
30873034-0	2019	Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.	icariin	0-7	mechanistic target of rapamycin kinase	Homo sapiens	145-149	
31424652-0	2019	Icariin inhibits the growth of human cervical cancer cells by inducing apoptosis and autophagy by targeting mTOR/PI3K/AKT signalling pathway.	icariin	0-7	mechanistic target of rapamycin kinase	Homo sapiens	108-112	
31424652-15	2019	Icariin also induced the generation of ROS and diminished the MMP levels in HeLa cells and blocked the mTOR/PI3K/AKT signalling cascade, suggestive of its potent anticancer activity.	icariin	0-7	mechanistic target of rapamycin kinase	Homo sapiens	103-107	
29808793-0	2018	Icariin inhibits autophagy and promotes apoptosis in SKVCR cells through mTOR signal pathway.	icariin	0-7	mechanistic target of rapamycin kinase	Homo sapiens	73-77	
29808793-10	2018	Icariin can inhibit autophagy and promote apoptosis in SKVCR cells by activating mTOR signal pathway.	icariin	0-7	mechanistic target of rapamycin kinase	Homo sapiens	81-85	
25787271-7	2015	These antiapoptotic and antiautophagic effects of Icariin are possibly mediated by restoring the loss of mammalian target of rapamycin /p70S6K/4EBP1 phosphorylation as well as attenuation of ATF2 and ERK1/2 protein levels after H2 O2 treatment.	icariin	50-57	mechanistic target of rapamycin kinase	Homo sapiens	105-134