PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33891785-10	2021	In addition, ICA significantly increased the expression of P47phox and iNOS, decreased p-JNK/JNK, p-P38/P38, Bax/Bcl-2, active caspase-3, and active caspase-9.	icariin	13-16	BCL2 associated X, apoptosis regulator	Homo sapiens	109-112	
29960293-5	2017	Reversetranscription polymerase chain reaction and enzyme-linked immunosorbent assays were usedto determine the effects of icariin on the expression of Fas, FasL, Bcl-2, and Bax.	icariin	123-130	BCL2 associated X, apoptosis regulator	Homo sapiens	174-177	
20674153-2	2010	Icariin triggered the mitochondrial/caspase apoptotic pathway indicated by enhanced Bax-to-Bcl-2 ratio, loss of mitochondrial membrane potential, cytochrome c release, and caspase cascade.	icariin	0-7	BCL2 associated X, apoptosis regulator	Homo sapiens	84-87	
35114909-7	2022	The assay results demonstrated that ICA can promote the apoptosis of SKOV3 cells as indicated by the proapoptotic markers Bax, Bcl-xl and Caspase-3 and the key factors of the NF-(Formula: see text)B signaling pathway (NF-(Formula: see text)Bp65, p-NF-(Formula: see text)Bp65, p-I(Formula: see text)B(Formula: see text) and I(Formula: see text)B(Formula: see text).	icariin	36-39	BCL2 associated X, apoptosis regulator	Homo sapiens	122-125	
30551489-7	2019	Moreover, icariin pretreatment significantly reduced cellular apoptosis via reduced levels of Bax, cleaved caspase-3/9, and increased anti-apoptotic protein Bcl-2 in the cells.	icariin	10-17	BCL2 associated X, apoptosis regulator	Homo sapiens	94-97	
31424652-13	2019	The anticancer effects of Icariin were due to induction of apoptosis which was accompanied with cleavage of caspase 3 and 9, upregulation of Bax and downregulation of Bcl-2.	icariin	26-33	BCL2 associated X, apoptosis regulator	Homo sapiens	141-144	
30551506-8	2019	ICA significantly suppressed cell viability in a dose-dependent manner and induced apoptosis by regulating Bcl-2, Bax and cleaced-Caspase-3/-9 expression in SW579 and TPC1 cells (p < 0.001).	icariin	0-3	BCL2 associated X, apoptosis regulator	Homo sapiens	114-117	
30088538-13	2018	Icariin repressed colon carcinoma cell line HCT116 by enhancing p53 expression and activating p53 functions possibly through Bcl-2/Bax imbalance and caspase-9 and -3 regulation.	icariin	0-7	BCL2 associated X, apoptosis regulator	Homo sapiens	131-134