PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33743412-0	2021	Icariin stimulates osteogenesis and suppresses adipogenesis of human bone mesenchymal stem cells via miR-23a-mediated activation of the Wnt/beta-catenin signaling pathway.	icariin	0-7	catenin beta 1	Homo sapiens	140-152	
33743412-14	2021	Notably, ICA-induced activation of the Wnt/beta-catenin signaling pathway was significantly attenuated following miR-23a up-regulation.	icariin	9-12	catenin beta 1	Homo sapiens	43-55	
33849528-0	2021	Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-kappaB and Wnt/beta-catenin pathways.	icariin	13-20	catenin beta 1	Homo sapiens	142-154	
33849528-11	2021	For the part of mechanism exploration, we showed that ICA inhibits the inflammation, proliferation, migration, and invasion, as well as promotes apoptosis and immunity in cervical cancer through impairment of TLR4/MyD88/NF-kappaB and Wnt/beta-catenin pathways.	icariin	54-57	catenin beta 1	Homo sapiens	238-250	
24295650-11	2014	In addition, treatment with Icariin was associated with lower levels of phosphorylated p38, phosphorylated JNK, and beta-catenin in both IL-1beta-induced SW1353 chondrosarcoma cells and in the rat OA model.	icariin	28-35	catenin beta 1	Homo sapiens	116-128	
30720119-6	2019	ICA inhibited the expression of fuse binding protein 1 (FBP1), a critical regulator of proliferation and tumorigenesis through binding to the c-Myc promoter, as well as beta-catenin, a key regulator in ovarian cancer initiation, metastasis, chemoresistance and recurrence.	icariin	0-3	catenin beta 1	Homo sapiens	169-181	
30008817-0	2018	Inhibitory effect of icariin on osteosarcoma cell proliferation via the Wnt/beta-catenin signaling pathway.	icariin	21-28	catenin beta 1	Homo sapiens	76-88	
30008817-3	2018	The present study was conducted to investigate the effects of icariin (ICA) on osteosarcoma cell proliferation and to investigate the role of the Wnt/beta-catenin signaling pathway in the inhibition process of ICA on osteosarcoma cell proliferation.	icariin	210-213	catenin beta 1	Homo sapiens	150-162	
30008817-7	2018	The expression levels of related and apoptotic proteins in the Wnt/beta-catenin signaling pathway using ICA were detected by semi-quantitative PCR and western blot analysis, respectively.	icariin	104-107	catenin beta 1	Homo sapiens	67-79	
27029606-8	2016	To confirm icariin mediated its bone-protective effects via the Wnt/beta-catenin signaling pathway, we demonstrated that ICG-001, a selective Wnt/beta-catenin inhibitor, attenuated the effects of icariin on MSC mineralization in vitro and bone formation in vivo.	icariin	196-203	catenin beta 1	Homo sapiens	68-80	
27029606-9	2016	Therefore, icariin could induce osteogenic differentiation of MSCs and promote new bone formation at a titanium-particle-induced osteolytic site via activation of the Wnt/beta-catenin signaling pathway.	icariin	11-18	catenin beta 1	Homo sapiens	171-183	
30008817-12	2018	Semi-quantitative PCR and western blot analysis revealed that the expression levels of p-GSK3beta, beta-catenin, c-Myc and cyclin D1 in cells after ICA treatment were significantly downregulated (p<0.01), while the expression level of caspase-3 was significantly increased (p<0.01).	icariin	148-151	catenin beta 1	Homo sapiens	99-111	
30008817-14	2018	Thus, ICA can significantly inhibit osteosarcoma cell proliferation and promote osteosarcoma cell apoptosis, which may be realized by affecting the expression of the Wnt/beta-catenin signaling pathway and blocking the expression of related proteins.	icariin	6-9	catenin beta 1	Homo sapiens	170-182	
27029606-7	2016	Mechanistically, icariin inhibited decreased beta-catenin stability induced by titanium particles in vivo and in vitro.	icariin	17-24	catenin beta 1	Homo sapiens	45-57	
27029606-8	2016	To confirm icariin mediated its bone-protective effects via the Wnt/beta-catenin signaling pathway, we demonstrated that ICG-001, a selective Wnt/beta-catenin inhibitor, attenuated the effects of icariin on MSC mineralization in vitro and bone formation in vivo.	icariin	11-18	catenin beta 1	Homo sapiens	68-80	
27029606-8	2016	To confirm icariin mediated its bone-protective effects via the Wnt/beta-catenin signaling pathway, we demonstrated that ICG-001, a selective Wnt/beta-catenin inhibitor, attenuated the effects of icariin on MSC mineralization in vitro and bone formation in vivo.	icariin	11-18	catenin beta 1	Homo sapiens	146-158