PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28447732-7	2017	The results of the present study demonstrated that Icariin inhibited the expression of MMP-1, MMP-3, MMP-13, P-p38, P-ERK and P-JNK.	icariin	51-58	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	116-121	
26507164-9	2015	Icariin treatment resulted in a reduced expression of p-P38 and p-ERK signal activation induced by TNF-alpha/IFN-gamma; however, only SB203580, the p38 alpha/beta inhibitor, inhibited the secretion of inflammatory cytokines induced by TNF-alpha/IFN-gamma in cultured HaCaT cells.	icariin	0-7	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	64-69	
26049256-4	2015	Furthermore, ICA treatment increased the expression of ERS-related molecules (p-PERK, ATF6, GRP78, p-eIF2alpha, and CHOP), up-regulated the apoptosis-related protein PUMA and down-regulated the anti-apoptosis-related protein Bcl2.	icariin	13-16	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	80-84	
26049256-6	2015	Additionally, ICA inhibited the growth of human lung adenocarcinoma A549 cell xenografts by increasing the expression of ERS-related molecules (p-PERK and CHOP), up-regulating PUMA, and down-regulating Bcl2.	icariin	14-17	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	146-150