PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34803431-0 2021 Ginsenoside Rg3 attenuates skin disorders via down-regulation of MDM2/HIF1alpha signaling pathway. ginsenoside Rg3 0-15 hypoxia inducible factor 1 subunit alpha Homo sapiens 70-79 33639908-0 2021 Ginsenoside Rg3 inhibits pulmonary fibrosis by preventing HIF-1alpha nuclear localisation. ginsenoside Rg3 0-15 hypoxia inducible factor 1 subunit alpha Homo sapiens 58-68 33639908-6 2021 In addition, biacore was used to detect the binding between ginsenoside Rg3 and HIF-1alpha. ginsenoside Rg3 60-75 hypoxia inducible factor 1 subunit alpha Homo sapiens 80-90 33639908-8 2021 In addition, molecular docking and biacore results indicated that ginsenoside Rg3 can bind HIF-1alpha. ginsenoside Rg3 66-81 hypoxia inducible factor 1 subunit alpha Homo sapiens 91-101 33639908-9 2021 Therefore, Ginsenoside Rg3 can slow down the progression of pulmonary fibrosis by inhibiting the nuclear localisation of HIF-1alpha. ginsenoside Rg3 11-26 hypoxia inducible factor 1 subunit alpha Homo sapiens 121-131 31939450-1 2019 Objective: The aim of this study is to probe in the inhibitory effects of ginsenoside Rg3 on the expression of hypoxia-induced factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in human gastric cancer cells. ginsenoside Rg3 74-89 hypoxia inducible factor 1 subunit alpha Homo sapiens 142-152 31939450-3 2019 Results: Under hypoxia, expression of HIF-1alpha and VEGF in human gastric cancer BGC823 cells showed an increasing trend, and that was remarkably lower in experiment group than in the control group after applying Rg3, which was obvious at 12 and 24 h (P < 0.05). ginsenoside Rg3 214-217 hypoxia inducible factor 1 subunit alpha Homo sapiens 38-48 31939450-4 2019 Conclusion: Rg3 can inhibit expression of HIF-1alpha and VEGF in human gastric cancer cells and may influence abdominal implantation metastasis of gastric cancer through inhibiting its expression. ginsenoside Rg3 12-15 hypoxia inducible factor 1 subunit alpha Homo sapiens 42-52