PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34916608-10	2021	We showed that a high dose of Rg3 (30 mg   kg-1  d-1) significantly decreased the content of N-acetylglutamine, increased the expression of ACY1, and inhibited TGF-beta1/Smad3 pathway in CAL mice; Rg3 (25 muM) exerted similar effects in Ang II-treated MCFs.	ginsenoside Rg3	30-33	transforming growth factor, beta 1	Mus musculus	160-169	
34916608-12	2021	In Ang II-treated MCFs, the effects of Rg3 on collagen deposition and TGF-beta1/Smad3 pathway were slightly enhanced by overexpression of ACY1, whereas ACY1 siRNA partially weakened the beneficial effects of Rg3, suggesting that Rg3 might suppress myocardial fibrosis through ACY1.	ginsenoside Rg3	39-42	transforming growth factor, beta 1	Mus musculus	70-79	
34916608-12	2021	In Ang II-treated MCFs, the effects of Rg3 on collagen deposition and TGF-beta1/Smad3 pathway were slightly enhanced by overexpression of ACY1, whereas ACY1 siRNA partially weakened the beneficial effects of Rg3, suggesting that Rg3 might suppress myocardial fibrosis through ACY1.	ginsenoside Rg3	229-232	transforming growth factor, beta 1	Mus musculus	70-79	
34916608-14	2021	Rg3 attenuates myocardial fibrosis to ameliorate HF through increasing ACY1 expression and inhibiting TGF-beta1/Smad3 pathway, which provides some references for further development of anti-fibrotic drugs for HF.	ginsenoside Rg3	0-3	transforming growth factor, beta 1	Mus musculus	102-111	
34694773-4	2021	First, we found that Rg3 attenuated Al-induced bone impairment in vivo and in vitro by relieving structural damage to the femur, increasing MC3T3-E1 cell activity, differentiation, mineralization, inhibition of cell apoptosis, and upregulating the extracellular matrix (ECM) synthesis and the expression of TGF-beta1/Smad signaling pathway key factors.	ginsenoside Rg3	21-24	transforming growth factor, beta 1	Mus musculus	307-316	
34694773-5	2021	Subsequently, in the signal pathway intervention experiment, the protective effect of Rg3 on bone impairment induced by Al was weakened; these results indicate that activating the TGF-beta1/Smad signaling pathway is one of the mechanisms of Rg3-attenuated Al-induced bone impairment.	ginsenoside Rg3	86-89	transforming growth factor, beta 1	Mus musculus	180-189	
34694773-5	2021	Subsequently, in the signal pathway intervention experiment, the protective effect of Rg3 on bone impairment induced by Al was weakened; these results indicate that activating the TGF-beta1/Smad signaling pathway is one of the mechanisms of Rg3-attenuated Al-induced bone impairment.	ginsenoside Rg3	241-244	transforming growth factor, beta 1	Mus musculus	180-189