PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33843270-10	2021	Furthermore, upregulation of V2R and AQP2 mRNA and phosphorylated CREB was induced by haloperidol, sertraline, or carbamazepine and was blocked by tolvaptan cotreatment.	Tolvaptan	147-156	aquaporin 2	Rattus norvegicus	37-41	
33843270-9	2021	AQP2 membrane trafficking was induced by haloperidol, sertraline, or carbamazepine and was also blocked by cotreatment with tolvaptan or a PKA inhibitor.	Tolvaptan	124-133	aquaporin 2	Rattus norvegicus	0-4	
27022218-0	2016	Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites.	Tolvaptan	0-9	aquaporin 2	Rattus norvegicus	20-31	
30426292-8	2019	Notably, aquaporin 2 redistribution from the apical to intracellular domains was observed in tolvaptan-treated rats and was partially reversed in the tolvaptan + HCTZ group.	Tolvaptan	93-102	aquaporin 2	Rattus norvegicus	9-20	
30426292-8	2019	Notably, aquaporin 2 redistribution from the apical to intracellular domains was observed in tolvaptan-treated rats and was partially reversed in the tolvaptan + HCTZ group.	Tolvaptan	150-159	aquaporin 2	Rattus norvegicus	9-20	
27478876-8	2016	Metformin increased protein abundance of inner medullary urea transporter UT-A1 by 61% and aquaporin 2 (AQP2) by 44% in tolvaptan-treated rats, and immunohistochemistry showed increased membrane accumulation of AQP2 with acute and chronic AMPK stimulation.	Tolvaptan	120-129	aquaporin 2	Rattus norvegicus	91-102	
27478876-8	2016	Metformin increased protein abundance of inner medullary urea transporter UT-A1 by 61% and aquaporin 2 (AQP2) by 44% in tolvaptan-treated rats, and immunohistochemistry showed increased membrane accumulation of AQP2 with acute and chronic AMPK stimulation.	Tolvaptan	120-129	aquaporin 2	Rattus norvegicus	104-108	
27478876-8	2016	Metformin increased protein abundance of inner medullary urea transporter UT-A1 by 61% and aquaporin 2 (AQP2) by 44% in tolvaptan-treated rats, and immunohistochemistry showed increased membrane accumulation of AQP2 with acute and chronic AMPK stimulation.	Tolvaptan	120-129	aquaporin 2	Rattus norvegicus	211-215	
27022218-9	2016	After administration of tolvaptan, AQP-2 expression began to decrease significantly from day 2 in each treatment group, but no significant difference was finally found between the treatment groups.	Tolvaptan	24-33	aquaporin 2	Rattus norvegicus	35-40	
24305472-7	2014	The tolvaptan infusion produced large decreases in the renal abundance of aquaporin-2 (AQP2), aquaporin-3 (AQP3), the beta-subunit of the epithelial sodium channel (beta-ENaC), and gamma-ENaC that were comparable to the differences seen in vehicle-infused vs. vasopressin-infused Brattleboro rats.	Tolvaptan	4-13	aquaporin 2	Rattus norvegicus	74-85	
24305472-7	2014	The tolvaptan infusion produced large decreases in the renal abundance of aquaporin-2 (AQP2), aquaporin-3 (AQP3), the beta-subunit of the epithelial sodium channel (beta-ENaC), and gamma-ENaC that were comparable to the differences seen in vehicle-infused vs. vasopressin-infused Brattleboro rats.	Tolvaptan	4-13	aquaporin 2	Rattus norvegicus	87-91	
24305472-9	2014	We also provide ancillary in vitro data in rat inner-medullary-collecting-duct suspensions showing that tolvaptan can block vasopressin"s effects on phosphorylation of the water channel AQP2 in vitro.	Tolvaptan	104-113	aquaporin 2	Rattus norvegicus	186-190	
24305472-10	2014	Specifically, tolvaptan almost completely inhibited the ability of vasopressin to increase AQP2 phosphorylation at Ser256, Ser264, and Ser269, while strongly inhibiting a vasopressin-induced decrease in AQP2 phosphorylation at Ser261.	Tolvaptan	14-23	aquaporin 2	Rattus norvegicus	91-95	
26109089-7	2015	Moreover, AQP2 upregulation and cAMP accumulation in response to 4-HC were significantly reduced by tolvaptan cotreatment in primary cultured IMCD cells and IMCD suspensions, respectively.	Tolvaptan	100-109	aquaporin 2	Rattus norvegicus	10-14	
24305472-10	2014	Specifically, tolvaptan almost completely inhibited the ability of vasopressin to increase AQP2 phosphorylation at Ser256, Ser264, and Ser269, while strongly inhibiting a vasopressin-induced decrease in AQP2 phosphorylation at Ser261.	Tolvaptan	14-23	aquaporin 2	Rattus norvegicus	203-207