PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18473752-3	2008	The present study prospectively examined the possible relationship between the toxicity and efficacy of capecitabine and 14 different polymorphisms in CES 2, CDD, TS and DPD.	Capecitabine	104-116	carboxylesterase 2	Homo sapiens	151-156	
28126414-3	2017	hCE1 is known to play crucial roles in the metabolism of a wide variety of endogenous esters, clinical drugs and insecticides, while hCE2 plays a key role in the metabolic activation of anticancer agents including irinotecan and capecitabine.	Capecitabine	229-241	carboxylesterase 2	Homo sapiens	133-137	
27569869-4	2016	Capecitabine is activated to 5-FU by CES, CDA and TYMP, of which SNPs in CDA and CES2 were found to be associated with efficacy and toxicity.	Capecitabine	0-12	carboxylesterase 2	Homo sapiens	81-85	
18473752-0	2008	A carboxylesterase 2 gene polymorphism as predictor of capecitabine on response and time to progression.	Capecitabine	55-67	carboxylesterase 2	Homo sapiens	2-20	
18473752-1	2008	Capecitabine is a drug that requires the consecutive action of three enzymes: carboxylesterase 2 (CES 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP) for transformation into 5-fluorouracil (5FU).	Capecitabine	0-12	carboxylesterase 2	Homo sapiens	78-96	
18473752-1	2008	Capecitabine is a drug that requires the consecutive action of three enzymes: carboxylesterase 2 (CES 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP) for transformation into 5-fluorouracil (5FU).	Capecitabine	0-12	carboxylesterase 2	Homo sapiens	98-103	
28827188-0	2018	Single-nucleotide polymorphisms in the genes of CES2, CDA and enzymatic activity of CDA for prediction of the efficacy of capecitabine-containing chemotherapy in patients with metastatic breast cancer.	Capecitabine	122-134	carboxylesterase 2	Homo sapiens	48-52	
28827188-12	2018	Since particular SNPs in CDA and CES2 were associated with benefit from the addition of capecitabine to AT, their predictive value should be explored in a higher number of patients.	Capecitabine	88-100	carboxylesterase 2	Homo sapiens	33-37	
29210644-4	2018	CES2 plays crucial roles in the metabolic activation of many prodrugs including anticancer agents capecitabine and CPT-11.	Capecitabine	98-110	carboxylesterase 2	Homo sapiens	0-4	
18473752-7	2008	For the first time, an association between a polymorphism in the CES2 gene and the efficacy of capecitabine has been described, providing preliminary evidence of its predictive and prognostic value.	Capecitabine	95-107	carboxylesterase 2	Homo sapiens	65-69	
15687373-0	2005	Hydrolysis of capecitabine to 5"-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide.	Capecitabine	14-26	carboxylesterase 2	Homo sapiens	65-82	
15687373-2	2005	A three-step in vivo-targeted activation process requiring carboxylesterases, cytidine deaminase, and thymidine phosphorylase converts capecitabine to 5-fluorouracil.	Capecitabine	135-147	carboxylesterase 2	Homo sapiens	59-76	
15687373-3	2005	Carboxylesterases hydrolyze capecitabine"s carbamate side chain to form 5"-deoxy-5-fluorocytidine (5"-DFCR).	Capecitabine	28-40	carboxylesterase 2	Homo sapiens	0-17	
15687373-4	2005	This study examines the steady-state kinetics of recombinant human carboxylesterase isozymes carboxylesterase (CES) 1A1, CES2, and CES3 for hydrolysis of capecitabine with a liquid chromatography/mass spectroscopy assay.	Capecitabine	154-166	carboxylesterase 2	Homo sapiens	121-125	
15687373-5	2005	Additionally, a spectrophotometric screening assay was utilized to identify drugs that may inhibit carboxylesterase activation of capecitabine.	Capecitabine	130-142	carboxylesterase 2	Homo sapiens	99-115	
15687373-6	2005	CES1A1 and CES2 hydrolyze capecitabine to a similar extent, with catalytic efficiencies of 14.7 and 12.9 min(-1) mM(-1), respectively.	Capecitabine	26-38	carboxylesterase 2	Homo sapiens	11-15	
15687373-12	2005	Both CES1A1 and CES2 are responsible for the activation of capecitabine, whereas CES3 plays little role in 5"-DFCR formation.	Capecitabine	59-71	carboxylesterase 2	Homo sapiens	16-20