PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34824592-5 2021 The inhibitory activities of CJS-EO and positive control arbutin are further evaluated against mushroom tyrosinase. Arbutin 57-64 tyrosinase Mus musculus 104-114 7765966-3 1995 beta-Arbutin inhibited both tyrosinase activities from mushroom and mouse melanoma. Arbutin 0-12 tyrosinase Mus musculus 28-38 1920891-5 1991 Further, tyrosinase activity in crude preparations from B16 melanoma cells was inhibited by arbutin. Arbutin 92-99 tyrosinase Mus musculus 9-19 1920891-6 1991 From these results, it is suggested that arbutin can inhibit the melanogenesis by affecting not only the synthesis but also the activity of tyrosinase rather than by killing melanocytes B16 melanoma cells. Arbutin 41-48 tyrosinase Mus musculus 140-150 33821640-2 2021 Arbutin is an inhibitor of tyrosinase; however, its high polarity and weak transdermal absorption capacity limit its applications. Arbutin 0-7 tyrosinase Mus musculus 27-37 33821640-4 2021 Among the obtained esters, arbutin undecenoate (AU) showed the strongest tyrosinase-inhibiting activity (15.6%), which was 9.0 times higher than that of arbutin. Arbutin 27-34 tyrosinase Mus musculus 73-83 11023549-8 2000 Treatment with a high dose (20000 nmol) of PA alone for 3h enhanced oxidative stress by reducing glutathione levels in mouse skin, which was counteracted by the tyrosinase inhibitor arbutin. Arbutin 182-189 tyrosinase Mus musculus 161-171 29576710-10 2018 Conclusion: Our data implied that capsaicin could reverse the inhibitory effect of licochalcone A/beta-arbutin on tyrosinase expression in B16 mouse melanoma cells. Arbutin 98-110 tyrosinase Mus musculus 114-124 31027707-7 2019 In these cells, arbutin (a well-known tyrosinase inhibitor used as the positive control) only inhibited tyrosinase by 42.67% even at a concentration of 400 muM. Arbutin 16-23 tyrosinase Mus musculus 38-48 31027707-7 2019 In these cells, arbutin (a well-known tyrosinase inhibitor used as the positive control) only inhibited tyrosinase by 42.67% even at a concentration of 400 muM. Arbutin 16-23 tyrosinase Mus musculus 104-114 30892163-7 2019 RESULTS: The tyrosinase inhibitory concentration (IC50) for tested compounds was observed between the range of 68 to 0.0029 microg/ml with lowest IC50 value of compound 5c which outperforms than reference arbutin and kojic acid. Arbutin 205-212 tyrosinase Mus musculus 13-23 33581260-3 2021 In this work, Arbutin (Arb) and Vitamin C (Vc) mixed in 1:1 were found to have the greatest inhibition effects on melanogenesis and tyrosinase activity in B16 murine melanoma cells. Arbutin 14-21 tyrosinase Mus musculus 132-142 33581260-3 2021 In this work, Arbutin (Arb) and Vitamin C (Vc) mixed in 1:1 were found to have the greatest inhibition effects on melanogenesis and tyrosinase activity in B16 murine melanoma cells. Arbutin 14-17 tyrosinase Mus musculus 132-142 29207077-3 2018 In the present study, acetylated arbutin was prepared in order to improve the biological effects of arbutin, and it was found to significantly inhibit the biosynthesis of melanin and tyrosinase activity compared with parent arbutin in B16 murine melanoma cells. Arbutin 33-40 tyrosinase Mus musculus 183-193 29576710-0 2018 Capsaicin reverses the inhibitory effect of licochalcone A/beta-Arbutin on tyrosinase expression in b16 mouse melanoma cells. Arbutin 59-71 tyrosinase Mus musculus 75-85 29576710-8 2018 Results: Licochalcone A/beta-arbutin inhibited tyrosinase expression and further hindered melanin synthesis when applied individually to B16 mouse melanoma cells. Arbutin 24-36 tyrosinase Mus musculus 47-57 29576710-9 2018 However, licochalcone A/beta-arbutin combined with 50 mumol/L capsaicin enhanced the expression of tyrosinase in these cells and further increased melanin content. Arbutin 24-36 tyrosinase Mus musculus 99-109 29576710-13 2018 Licochalcone A/beta-arbutin inhibited tyrosinase expression and further hindered melanin synthesis when applied individually to B16 mouse melanoma cells. Arbutin 15-27 tyrosinase Mus musculus 38-48 29576710-14 2018 However, licochalcone A/beta-arbutin combined with 50 mumol/L capsaicin enhanced the expression of tyrosinase in these cells and further increased melanin content. Arbutin 24-36 tyrosinase Mus musculus 99-109 29576710-15 2018 Our research implied that capsaicin could reverse the inhibitory effect of licochalcone A/beta-arbutin on tyrosinase expression in B16 mouse melanoma cells. Arbutin 90-102 tyrosinase Mus musculus 106-116 19772488-4 2009 In contrast, arbutin displayed 9.1% inhibition of cellular tyrosinase activity and 29.5% inhibition of melanin production at the same concentration. Arbutin 13-20 tyrosinase Mus musculus 59-69 24189417-3 2013 Arbutin (Arb) is also known for its Tyr activity inhibitory effect and is commonly used as a skin-whitening agent. Arbutin 0-7 tyrosinase Mus musculus 36-39 24189417-3 2013 Arbutin (Arb) is also known for its Tyr activity inhibitory effect and is commonly used as a skin-whitening agent. Arbutin 0-3 tyrosinase Mus musculus 36-39 24189417-8 2013 On the other hand, Arb had no effect on the differentiation of melanocytes, and only suppressed melanogenesis by specifically suppressing elevations in Tyr expression in the late stage of differentiation. Arbutin 19-22 tyrosinase Mus musculus 152-155