PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20495075-2 2010 We have previously demonstrated that symmetric methylation of histone H4 Arginine 3 (H4R3me2s) by the protein arginine methyltransferase PRMT5 is required for recruitment of the DNA methyltransferase DNMT3A to the gamma-promoter, and subsequent DNA methylation and gene silencing. h4r3me2s 85-93 DNA methyltransferase 3 alpha Homo sapiens 200-206