PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22284780-11	2012	Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6.	oridonin	73-81	tumor necrosis factor	Homo sapiens	222-231	
31607286-5	2019	ELISA results indicated that IFN-gamma and TNF-beta release were significantly increased after oridonin treatment (P<0.05), however, the TNF-alpha release was not statistically different in comparison with control group (P>0.05).	oridonin	95-103	tumor necrosis factor	Homo sapiens	43-51	
31607286-6	2019	CONCLUSION: Oridonin can significantly improve killing efficiency of NK-92 MI on THP1, that might be related with up-regulation of MICB, ULBP1 and ULBP2 expression and promotion of IFN-gamma and TNF-beta release.	oridonin	12-20	tumor necrosis factor	Homo sapiens	195-203	
16399631-2	2006	We have reported that oridonin isolated from Rabdosia rubescens enhanced phagocytosis of apoptotic U937 cells by macrophage-like U937 cells through TNFalpha and IL-1beta release.	oridonin	22-30	tumor necrosis factor	Homo sapiens	148-156	
16079470-1	2005	Our previous study showed that oridonin isolated from Rabdosia rubescens enhanced phagocytosis of apoptotic cells by macrophage-like U937 cells through tumor necrosis factor (TNF) alpha and interleukin (IL)-1beta release.	oridonin	31-39	tumor necrosis factor	Homo sapiens	152-185	
16079470-7	2005	Furthermore, pretreatment of U937 cells with anti-TNFalpha and anti-IL-1beta antibodies blocked oridonin-induced phagocytic stimulation as well as phosphorylation of ERK, but did not block the activation of PKC, indicating that these signaling events are triggered by oridonin, whereas secreted TNFalpha or IL-1beta only activate the ERK-dependent pathway.	oridonin	96-104	tumor necrosis factor	Homo sapiens	50-58	
16079470-7	2005	Furthermore, pretreatment of U937 cells with anti-TNFalpha and anti-IL-1beta antibodies blocked oridonin-induced phagocytic stimulation as well as phosphorylation of ERK, but did not block the activation of PKC, indicating that these signaling events are triggered by oridonin, whereas secreted TNFalpha or IL-1beta only activate the ERK-dependent pathway.	oridonin	268-276	tumor necrosis factor	Homo sapiens	50-58	
15827331-5	2005	Oridonin also blocked tumor necrosis factor-alpha- and lipopolysaccharide-stimulated NF-kappa B activity in Jurkat cells as well as RAW264.7 murine macrophages.	oridonin	0-8	tumor necrosis factor	Homo sapiens	22-49	
15744069-5	2005	The oridonin-augmented phagocytosis was attenuated by anti-human TNFalpha and IL-1beta antisera, suggesting that TNFalpha and IL-1beta participate in the phagocytosis by oridonin-treated U937 cell-derived macrophages.	oridonin	4-12	tumor necrosis factor	Homo sapiens	65-73	
15744069-5	2005	The oridonin-augmented phagocytosis was attenuated by anti-human TNFalpha and IL-1beta antisera, suggesting that TNFalpha and IL-1beta participate in the phagocytosis by oridonin-treated U937 cell-derived macrophages.	oridonin	4-12	tumor necrosis factor	Homo sapiens	113-121	
15744069-5	2005	The oridonin-augmented phagocytosis was attenuated by anti-human TNFalpha and IL-1beta antisera, suggesting that TNFalpha and IL-1beta participate in the phagocytosis by oridonin-treated U937 cell-derived macrophages.	oridonin	170-178	tumor necrosis factor	Homo sapiens	65-73	
15744069-5	2005	The oridonin-augmented phagocytosis was attenuated by anti-human TNFalpha and IL-1beta antisera, suggesting that TNFalpha and IL-1beta participate in the phagocytosis by oridonin-treated U937 cell-derived macrophages.	oridonin	170-178	tumor necrosis factor	Homo sapiens	113-121	
15744069-7	2005	Taken together, oridonin facilitates the phagocytic activity against apoptotic cells through TNFalpha and IL-1beta release, which may be contribute to its antitumor activities.	oridonin	16-24	tumor necrosis factor	Homo sapiens	93-101