PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33125572-7 2021 This study indicated that the therapeutic effect of oridonin on experimental PI-IBS through repairing intestinal barrier function may be closely associated with the regulatory role of PXR/NF-kappaB signaling pathway. oridonin 52-60 nuclear factor kappa B subunit 1 Homo sapiens 188-197 33125572-0 2021 Oridonin Attenuates TNBS-induced Post-inflammatory Irritable Bowel Syndrome via PXR/NF-kappaB Signaling. oridonin 0-8 nuclear factor kappa B subunit 1 Homo sapiens 84-93 33125572-6 2021 Meanwhile, PXR and its target genes CYP3A4 and P-gp were induced by oridonin, which was associated with the decreased expression of NF-kappaB and the recovery of intestinal barrier. oridonin 68-76 nuclear factor kappa B subunit 1 Homo sapiens 132-141 30687752-9 2018 Additionally, oridonin blocked LPS-induced NF-kappaB p65 nuclear translocation and DNA binding activity. oridonin 14-22 nuclear factor kappa B subunit 1 Homo sapiens 43-52 33125572-5 2021 In Caco-2 cell lines, oridonin markedly inhibited LPS-induced NF-kappaB activation in a PXR-dependent manner. oridonin 22-30 nuclear factor kappa B subunit 1 Homo sapiens 62-71 32407876-4 2020 Next, cetuximab/oridonin significantly enhanced the mitochondrial apoptosis through NF-kappaB. oridonin 16-24 nuclear factor kappa B subunit 1 Homo sapiens 84-93 30687752-10 2018 Oridonin prevented LPS-stimulated NF-kappaB regulator IKKalpha/beta and IkappaBalpha phosphorylation and IkappaBalpha degradation. oridonin 0-8 nuclear factor kappa B subunit 1 Homo sapiens 34-43 30687752-11 2018 Combined treatment of oridonin and an Hsp70 substrate binding inhibitor synergistically suppressed LPS-stimulated proinflammatory cytokines and NF-kappaB pathway activation. oridonin 22-30 nuclear factor kappa B subunit 1 Homo sapiens 144-153 30687752-12 2018 Therefore, oridonin inhibits LPS-stimulated proinflammatory mediators through IKK/IkappaBalpha/NF-kappaB pathway. oridonin 11-19 nuclear factor kappa B subunit 1 Homo sapiens 95-104 26704389-0 2016 Inhibition of nuclear factor kappaB transcription activity drives a synergistic effect of cisplatin and oridonin on HepG2 human hepatocellular carcinoma cells. oridonin 104-112 nuclear factor kappa B subunit 1 Homo sapiens 29-35 30463731-0 2018 Antifibrosis Effect of Novel Oridonin Analog CYD0618 Via Suppression of the NF-kappaB Pathway. oridonin 29-37 nuclear factor kappa B subunit 1 Homo sapiens 76-85 28211965-0 2017 First Synthesis of an Oridonin-Conjugated Iridium(III) Complex for the Intracellular Tracking of NF-kappaB in Living Cells. oridonin 22-30 nuclear factor kappa B subunit 1 Homo sapiens 97-106 28211965-4 2017 In this work, we report a novel platform to track intracellular NF-kappaB by employing the conjugated iridium(III) complex 1, which was synthesized through the unique combination of a luminescent iridium(III) moiety with the natural product oridonin. oridonin 241-249 nuclear factor kappa B subunit 1 Homo sapiens 64-73 26704389-3 2016 Oridonin is a diterpenoid isolated from Rabdosia rubescens that can block the NF-kappaB signaling cascades. oridonin 0-8 nuclear factor kappa B subunit 1 Homo sapiens 81-87 25778647-2 2015 Specific NF-kappaB inhibitor oridonin abolished activation of proliferation and differentiation of progenitor cells. oridonin 29-37 nuclear factor kappa B subunit 1 Homo sapiens 9-18 26452790-8 2015 This strategy was also employed to detect the inhibition effect of oridonin, a known inhibitor of NF-kappaB. oridonin 67-75 nuclear factor kappa B subunit 1 Homo sapiens 98-107 22670565-0 2012 Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-kappaB-COX-2-IL-1beta pathway. oridonin 22-30 nuclear factor kappa B subunit 1 Homo sapiens 115-124 24288750-2 2013 NF-kappaB was found to participate in the proliferation and differentiation of progenitor elements that can be blocked by its specific inhibitor oridonin. oridonin 145-153 nuclear factor kappa B subunit 1 Homo sapiens 0-9 22670565-10 2012 NO augmented the oridonin-induced efferocytosis by mediating autophagy and activating the NF-kappaB-COX-2-IL-1beta pathway. oridonin 17-25 nuclear factor kappa B subunit 1 Homo sapiens 90-99 22155150-5 2012 Moreover, inhibition of extracellular signal-related kinase (ERK), nuclear factor-kappaB (NF-kappaB) and caspase-1 significantly suppressed oridonin-induced phagocytosis and autophagy. oridonin 140-148 nuclear factor kappa B subunit 1 Homo sapiens 67-88 22824908-0 2012 Downregulation of nucleoporin 88 and 214 induced by oridonin may protect OCIM2 acute erythroleukemia cells from apoptosis through regulation of nucleocytoplasmic transport of NF-kappaB. oridonin 52-60 nuclear factor kappa B subunit 1 Homo sapiens 199-208 22824908-8 2012 Taken together, these data suggest that oridonin has the potential to induce OCIM2 cell-apoptosis, involving NF-kappaB activation, whereas the downregulation of Nup88 and Nup214 may protect OCIM2 through the regulation of the nucleocytoplasmic transport of p65. oridonin 40-48 nuclear factor kappa B subunit 1 Homo sapiens 109-118 22155150-5 2012 Moreover, inhibition of extracellular signal-related kinase (ERK), nuclear factor-kappaB (NF-kappaB) and caspase-1 significantly suppressed oridonin-induced phagocytosis and autophagy. oridonin 140-148 nuclear factor kappa B subunit 1 Homo sapiens 90-99 22155150-6 2012 In addition, oridonin increased the protein levels of p-ERK, NF-kappaB, caspase-1 and pro IL-1beta. oridonin 13-21 nuclear factor kappa B subunit 1 Homo sapiens 61-70 22155150-11 2012 These results demonstrated that autophagy enhanced oridonin-induced phagocytosis through feedback regulation of ERK, NF-kappaB- and caspase-1-mediated IL-1beta release. oridonin 51-59 nuclear factor kappa B subunit 1 Homo sapiens 117-126 21398636-8 2011 In the presence of a known NF-kappaB inhibitor, oridonin, a reduction in the luminescence response of the ruthenium complex was observed. oridonin 48-56 nuclear factor kappa B subunit 1 Homo sapiens 27-36 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. oridonin 73-81 nuclear factor kappa B subunit 1 Homo sapiens 114-123 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. oridonin 73-81 nuclear factor kappa B subunit 1 Homo sapiens 125-134 16176802-0 2005 Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens. oridonin 161-169 nuclear factor kappa B subunit 1 Homo sapiens 74-83 19646415-0 2009 NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway. oridonin 22-30 nuclear factor kappa B subunit 1 Homo sapiens 0-9 19646415-3 2009 In addition, treatment with oridonin caused an increase in NF-kappaB and p53 activities in a time-dependent manner. oridonin 28-36 nuclear factor kappa B subunit 1 Homo sapiens 59-68 19646415-4 2009 Inhibition of NF-kappaB or p53 activation by its specific inhibitor PDTC or pifithrin-alpha respectively, significantly reduced both oridonin-induced apoptosis and autophagy accompanied by the decrease in Beclin 1 and LC3 levels. oridonin 133-141 nuclear factor kappa B subunit 1 Homo sapiens 14-23 19646415-5 2009 Further experiments confirmed that oridonin-induced p53 activation was reduced by the NF-kappaB inhibitor whereas the activation of NF-kappaB was not affected by p53 inhibition. oridonin 35-43 nuclear factor kappa B subunit 1 Homo sapiens 86-95 19646415-6 2009 Taken together, these results demonstrate that NF-kappaB promotes oridonin-induced apoptotic and autophagic cell death through regulating p53 activation in HT1080 cells. oridonin 66-74 nuclear factor kappa B subunit 1 Homo sapiens 47-56 16176802-13 2005 Decreases in p65 or p50 forms of NF-kappaB and its upstream regulator I-kappaB were found in oridonin-treated MCF-10A and not MCF-7 cells. oridonin 93-101 nuclear factor kappa B subunit 1 Homo sapiens 20-23 16176802-13 2005 Decreases in p65 or p50 forms of NF-kappaB and its upstream regulator I-kappaB were found in oridonin-treated MCF-10A and not MCF-7 cells. oridonin 93-101 nuclear factor kappa B subunit 1 Homo sapiens 33-42 15827331-0 2005 Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. oridonin 0-8 nuclear factor kappa B subunit 1 Homo sapiens 157-167 34971958-0 2022 Oridonin inhibits SASP by blocking p38 and NF-kappaB pathways in senescent cells. oridonin 0-8 nuclear factor kappa B subunit 1 Homo sapiens 43-52 15827331-4 2005 Further studies found that oridonin inhibited nuclear factor-kappa B (NF-kappa B) DNA-binding activity in these cells as measured by luciferase reporter gene, ELISA-based, and electrophoretic mobility shift assays. oridonin 27-35 nuclear factor kappa B subunit 1 Homo sapiens 46-68 15827331-4 2005 Further studies found that oridonin inhibited nuclear factor-kappa B (NF-kappa B) DNA-binding activity in these cells as measured by luciferase reporter gene, ELISA-based, and electrophoretic mobility shift assays. oridonin 27-35 nuclear factor kappa B subunit 1 Homo sapiens 70-80 15827331-5 2005 Oridonin also blocked tumor necrosis factor-alpha- and lipopolysaccharide-stimulated NF-kappa B activity in Jurkat cells as well as RAW264.7 murine macrophages. oridonin 0-8 nuclear factor kappa B subunit 1 Homo sapiens 85-95 15827331-6 2005 Of note, oridonin decreased survival of freshly isolated adult T-cell leukemia (three samples), acute lymphoblastic leukemia (one sample), chronic lymphocytic leukemia (one sample), non-Hodgkin"s lymphoma (three samples), and MM (four samples) cells from patients in association with inhibition of NF-kappa B DNA-binding activity. oridonin 9-17 nuclear factor kappa B subunit 1 Homo sapiens 298-308 34971958-11 2022 Therefore, the NF-kappaB and p38 pathways may contribute to the inhibition of SASP by oridonin. oridonin 86-94 nuclear factor kappa B subunit 1 Homo sapiens 15-24