PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28073841-8 2017 Data from tumor xenograft mouse models confirmed that everolimus-resistant cancer cells are sensitive to alisertib.Conclusions: Our results indicate that AURKA plays an important role in the activation of EIF4E and cap-dependent translation. MLN 8237 105-114 eukaryotic translation initiation factor 4E Mus musculus 205-210 28073841-9 2017 Targeting the AURKA-EIF4E-c-MYC axis using alisertib is a novel therapeutic strategy that can be applicable for everolimus-resistant tumors and/or subgroups of cancers that show overexpression of AURKA and activation of EIF4E and c-MYC. MLN 8237 43-52 eukaryotic translation initiation factor 4E Mus musculus 20-25 28073841-9 2017 Targeting the AURKA-EIF4E-c-MYC axis using alisertib is a novel therapeutic strategy that can be applicable for everolimus-resistant tumors and/or subgroups of cancers that show overexpression of AURKA and activation of EIF4E and c-MYC. MLN 8237 43-52 eukaryotic translation initiation factor 4E Mus musculus 220-225