PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25834401-0	2015	The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.	MLN 8237	46-55	mechanistic target of rapamycin kinase	Homo sapiens	144-148	
25834401-0	2015	The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.	MLN 8237	57-64	mechanistic target of rapamycin kinase	Homo sapiens	144-148	
25792811-0	2015	Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.	MLN 8237	74-83	mechanistic target of rapamycin kinase	Homo sapiens	231-235	
25792811-0	2015	Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.	MLN 8237	85-92	mechanistic target of rapamycin kinase	Homo sapiens	231-235	
28386317-0	2017	Alisertib induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt/mTOR- and p38 MAPK-mediated pathways in human glioblastoma cells.	MLN 8237	0-9	mechanistic target of rapamycin kinase	Homo sapiens	69-73	
25632225-0	2015	Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells.	MLN 8237	0-9	mechanistic target of rapamycin kinase	Homo sapiens	121-125	
29942081-5	2018	Incomplete inhibition of AURKA was a common source of therapy failure, and combinations of PI3K, AKT or mTOR inhibitors with the AURKA inhibitor MLN8237 were highly synergistic and durably suppressed mTOR signaling, resulting in apoptosis and tumor regression in vivo.	MLN 8237	145-152	mechanistic target of rapamycin kinase	Homo sapiens	104-108	
29942081-5	2018	Incomplete inhibition of AURKA was a common source of therapy failure, and combinations of PI3K, AKT or mTOR inhibitors with the AURKA inhibitor MLN8237 were highly synergistic and durably suppressed mTOR signaling, resulting in apoptosis and tumor regression in vivo.	MLN 8237	145-152	mechanistic target of rapamycin kinase	Homo sapiens	200-204	
27177156-0	2016	Alisertib induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells.	MLN 8237	0-9	mechanistic target of rapamycin kinase	Homo sapiens	68-72