PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34896433-0 2022 Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter. MLN 8237 0-9 ATP binding cassette subfamily C member 1 Homo sapiens 204-209 34896433-3 2022 In accumulation assays, alisertib potently inhibited ABCC1 transporter, but not ABCB1 or ABCG2. MLN 8237 24-33 ATP binding cassette subfamily C member 1 Homo sapiens 53-58 34896433-6 2022 Drug combination studies revealed the capability of alisertib to synergistically antagonize ABCC1-mediated resistance to daunorubicin. MLN 8237 52-61 ATP binding cassette subfamily C member 1 Homo sapiens 92-97