PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9490065-7	1998	In liver microsomes, the demethylation of imipramine was essentially due to CYP1A2 and to a smaller extent to CYP3A.	Imipramine	42-52	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	110-115	
15199661-1	2004	Tricyclic antidepressants are all hydroxylated by cytochrome P450 (CYP) 2D6, but the tertiary amines, amitriptyline, clomipramine and imipramine, are also N-demethylated to the active metabolites, nortriptyline, N-desmethylclomipramine and desipramine, by several CYPs, including the polymorphic CYP2C19, CYP1A2 and CYP3A4.	Imipramine	134-144	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	316-322	
16141545-3	2005	Among the recombinant CYPs, CYP3A4 exhibited the highest metabolic activities of all compounds except for clotiazepam and imipramine.	Imipramine	122-132	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	28-34	
9490065-8	1998	In fetuses and early neonates, CYP3A proteins were responsible for the low demethylation of imipramine (3-4% of the adult activity) before the onset of CYP1A2 and the subsequent rise of activity.	Imipramine	92-102	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	31-36	
9505989-3	1997	Imipramine pharmacokinetics serve as a marker for hepatic CYP2D6, CYP1A2, CYP3A activity.	Imipramine	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	74-79	
9278210-1	1997	AIMS: In vitro data indicate that imipramine (IMI), a widely used tricyclic antidepressant drug, is N-demethylated by several isoforms of cytochrome P450, which include CYP3A4.	Imipramine	34-44	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	169-175	
9278210-1	1997	AIMS: In vitro data indicate that imipramine (IMI), a widely used tricyclic antidepressant drug, is N-demethylated by several isoforms of cytochrome P450, which include CYP3A4.	Imipramine	46-49	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	169-175	
9088587-6	1997	CONCLUSIONS: These findings indicate that ketoconazole, a relatively specific inhibitor of CYP3A4, inhibits the N-demethylation of imipramine without affecting the 2-hydroxylation of imipramine and desipramine.	Imipramine	131-141	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	91-97	
9084457-0	1997	Imipramine demethylation in vivo: impact of CYP1A2, CYP2C19, and CYP3A4.	Imipramine	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	65-71	
9084457-2	1997	At least three different P450s appear to be responsible for the N-demethylation of imipramine to desipramine in vivo: CYP1A2, CYP2C19, and CYP3A4.	Imipramine	83-93	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-145